HLA class II involvement in HIV-associated Toxoplasmic encephalitis development
| Autor: | Horacio Salomón, Adrián Sorrentino, Karina Marinic, Jorge Quarleri, Ernesto Iliovich, Roxana López, Andrea E. Rubio, Alicia Habegger de Sorrentino, Patricia Motta |
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| Rok vydání: | 2005 |
| Předmět: |
Immunology
Argentina Biology Asymptomatic Gene Frequency Acquired immunodeficiency syndrome (AIDS) HLA-DQ Antigens Immunopathology medicine HLA-DQ beta-Chains Humans Immunology and Allergy Genetic Predisposition to Disease Sida Genotyping AIDS-Related Opportunistic Infections HLA-DR Antigens medicine.disease biology.organism_classification Toxoplasmosis Phenotype Case-Control Studies Toxoplasmosis Cerebral HIV-1 Encephalitis Viral disease medicine.symptom |
| Zdroj: | Clinical Immunology. 115:133-137 |
| ISSN: | 1521-6616 |
| Popis: | A total of 220 individuals were included in this study, 112 HIV-seronegative healthy individuals and 108 HIV-1-infected patients involving: 18 AIDS patients with Toxoplasmic encephalitis (AIDS-TE), 49 AIDS patients without TE, and 41 asymptomatic patients, were genotyping for DR and DQ loci by molecular biology techniques. Fisher's Exact test was used for statistical analysis. HLA-DQB*0402 and DRB1*08 alleles were associated with a high risk to develop opportunistic infections with neurological involvement, mainly Toxoplasma encephalitis in relationship with subjects healthy (OR = 20.43; Pc = 7.0 × 10 −6 and OR = 11; Pc = 2.6 × 10 −4 , respectively); in relationship with AIDS no TE (OR = 6.98; Pc = 0.028 and OR = 4.85; P = 0.012, Pc = 0.14) and with patients in asymptomatic stage (OR = 61.50, Pc = 8.4 × 10 −6 and OR = 19.38; Pc = 3.9 × 10 −4 ), respectively. Conclusions It was concluded that the presence of HLA-DQB*0402 and DRB1*08 alleles in HIV-1-positive patients could be considered risk factors for developing neurological opportunistic infections, mainly Toxoplasmic encephalitis. |
| Databáze: | OpenAIRE |
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