Assessment of cellular response to mitogens in long-term allogeneic hematopoietic stem cell transplantation survivors
| Autor: | Yukiyasu Ozawa, Aika Seto, Marie Ohbiki, Koichi Miyamura, Miyo Goto, Takahiko Sato, Tatsunori Goto, Takanobu Morishita |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty Long term follow up medicine.medical_treatment Graft vs Host Disease chemical and pharmacologic phenomena Hematopoietic stem cell transplantation Lymphocyte Activation Severity of Illness Index Mitogen stimulation Leukocyte Count Immune system Transplantation Immunology Internal medicine Medicine Humans Transplantation Homologous Significant risk Prospective Studies Survivors Immunity Cellular Hematology business.industry Hematopoietic Stem Cell Transplantation Transplantation surgical procedures operative Allogeneic hsct Mitogens business |
| Zdroj: | International journal of hematology. 114(6) |
| ISSN: | 1865-3774 |
| Popis: | Infection is one of the major causes of death in hematopoietic stem cell transplantation (HSCT) survivors. Precise assessments of immune function after HSCT will be critical in establishing appropriate treatment and prophylaxis, such as re-vaccination. Although several surrogate markers for prediction of clinical outcomes after HSCT have been proposed, definitive markers of immune reconstitution and data on those markers in long-term survivors are lacking. In this study, cellular response to mitogens was assessed and clinical features associated with a poor response to mitogens were investigated in long-term allogeneic HSCT survivors. Age at transplantation and age at the time of mitogen stimulation test were each identified as significant risk factors for poor response to phytohemagglutinin and concanavalin A, respectively (P |
| Databáze: | OpenAIRE |
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