An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing
| Autor: | Anke M. Hövels, Roger Tavendale, Colin N. A. Palmer, Stephen Bremner, Patrícia Soares, Christina J Jones, Jessie Felton, Katy Fidler, Somnath Mukhopadhyay |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Adolescent Genotype Immunology Antigen presentation Immunoglobulin E Polymorphism Single Nucleotide Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Immune system Polymorphism (computer science) medicine Immunology and Allergy Humans Lectins C-Type Practice Patterns Physicians' Receptor Child Asthma biology business.industry Receptors IgE Atopic dermatitis medicine.disease Rhinitis Allergic 030104 developmental biology 030228 respiratory system Child Preschool biology.protein Leukotriene Antagonists Female business |
| Zdroj: | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical ImmunologyREFERENCES. 51(8) |
| ISSN: | 1365-2222 0954-7894 |
| Popis: | The Fc Fragment of IgE Receptor II (FCER2) is expressed in several cells, such as macrophages, eosinophils, B cells and platelets. Studies have suggested that FCER2 is involved in the regulation of IgE responses, growth and differentiation of T and B cells, cellular adherence and antigen presentation. The activation of the receptor results in down-regulation of IgE-mediated immune responses. Two studies found that individuals with asthma on inhaled corticosteroids (ICS) with the CC genotype of the rs28364072 polymorphism had a two-fold increased odds of asthma exacerbations and uncontrolled asthma than individuals with at least one copy of the T allele (CT/TT). |
| Databáze: | OpenAIRE |
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