Genetic Variants Associated with Colorectal Adenoma Susceptibility
| Autor: | Abulí, Anna, Castells Garangou, Antoni, Bujanda, Luis, Lozano, Juan José, Bessa i Caserras, Xavier, Hernández, Cristina, Álvarez Urturi, Cristina, Pellisé Urquiza, Maria, Esteban-Jurado, Clara, Hijona, Elizabeth, Burón, Andrea, Macià, Francesc, Grau Cano, J. (Jaume), Guayta, Rafael (Guayta Escolies), Castellví-Bel, Sergi, Andreu, Montserrat, Trilla García, Antoni, PROCOLON research group |
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| Přispěvatelé: | Universitat de Barcelona |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Oncology Heredity task-force Colorectal cancer lcsh:Medicine American-Cancer Society population Genome-wide association study Bioinformatics Gene Frequency Human genetics Risk Factors Medicine and Health Sciences genome -wide association lcsh:Science polyps risk education.field_of_study Multidisciplinary Genètica humana Genomics Colonoscopy Middle Aged Adenomas Genetic Mapping Estudi de casos loci surveillance Female Colorectal Neoplasms Risk assessment Còlon -- Càncer -- Aspectes genètics Research Article metaanalysis Adenoma Genotyping medicine.medical_specialty Genotype Population Surgical and Invasive Medical Procedures Variant Genotypes Colorectal adenoma Biology Genetic Predisposition Research and Analysis Methods Polymorphism Single Nucleotide Risk Assessment Digestive System Procedures 03 medical and health sciences Càncer colorectal Internal medicine Genome-Wide Association Studies Genetics medicine Genetic predisposition Humans Genetic Predisposition to Disease Molecular Biology Techniques education Molecular Biology Alleles Aged Colorectal Cancer lcsh:R Mutació (Biologia) polypectomy Case-control study Cancers and Neoplasms Biology and Life Sciences Computational Biology Colonoscòpia Human Genetics Mutation (Biology) Genome Analysis medicine.disease Logistic Models 030104 developmental biology Case-Control Studies Genetics of Disease Multivariate Analysis lcsh:Q Case studies Genome-Wide Association Study |
| Zdroj: | Addi. Archivo Digital para la Docencia y la Investigación instname Recercat. Dipósit de la Recerca de Catalunya PLoS ONE, Vol 11, Iss 4, p e0153084 (2016) Dipòsit Digital de la UB Universidad de Barcelona PLoS ONE |
| Popis: | Background Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (>= 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with >= 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population. This work was supported by grants from: Instituto de Salud Carlos III-FEDER (RD09/0076/00036), the Xarxa de Bancs de tumors sponsored by Pla Director d'Oncologia de Catalunya (XBTC), Fondo de Investigacion Sanitaria/FEDER (PI10/00918, PI11/00219, PI14/00173, PI14/00441), Ministerio de Economia y Competitividad (SAF2010-19273), Asociacion Espanola contra el Cancer (Fundacion Cientifica GCB13131592CAST), and COST Action BM1206 (SCB). SCB is supported by a contract from the Fondo de Investigacion Sanitaria (CP 03-0070) and Agencia de Gestio d'Ajuts Universitaris i de Recerca (Generalitat de Catalunya, 2014SGR255, 2014SGR135). CIBERehd is funded by the Instituto de Salud Carlos III. |
| Databáze: | OpenAIRE |
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