Preparative enantioseparation of propafenone by counter-current chromatography using di-n -butyl l-tartrate combined with boric acid as the chiral selector

Autor:	Xing-Nuo Li, Shengqiang Tong, Chu Chu, Jizhong Yan, Mangmang Shen, Ye Zheng
Rok vydání:	2013
Předmět:	Chloroform Chromatography Molecular Structure Liquid-Liquid Extraction chemistry.chemical_element Stereoisomerism Filtration and Separation Propafenone Tartrate High-performance liquid chromatography Analytical Chemistry Boric acid chemistry.chemical_compound Countercurrent chromatography Boric Acids chemistry medicine Enantiomer Boron Countercurrent Distribution Tartrates medicine.drug
Zdroj:	Journal of Separation Science. 36:3101-3106
ISSN:	1615-9306
Popis:	This paper extends the research of the utilization of borate coordination complexes in chiral separation by counter-current chromatography (CCC). Racemic propafenone was successfully enantioseparated by CCC with di-n-butyl l-tartrate combined with boric acid as the chiral selector. The two-phase solvent system was composed of chloroform/ 0.05 mol/L acetate buffer pH 3.4 containing 0.10 mol/L boric acid (1:1, v/v), in which 0.10 mol/L di-n-butyl l-tartrate was added in the organic phase. The influence of factors in the enantioseparation of propafenone were investigated and optimized. A total of 92 mg of racemic propafenone was completely enantioseparated using high-speed CCC in a single run, yielding 40-42 mg of (R)- and (S)-propafenone enantiomers with an HPLC purity over 90-95%. The recovery for propafenone enantiomers from fractions of CCC was in the range of 85-90%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80390aefeea89cb84da8a77165c5f47d https://doi.org/10.1002/jssc.201300614 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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