Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension

Autor: Naoki Inui, Hironao Hozumi, Hiroshi Watanabe, Noriyuki Enomoto, Masato Maekawa, Takamichi Ishikawa, Kensuke Kataoka, Seiichiro Suzuki, Yasuhiro Kondoh, Keiichi Odagiri, Takafumi Suda, Masato Karayama, Tomoyuki Fujisawa, Kazuki Furuhashi, Yuzo Suzuki, Yutaro Nakamura
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
Male
medicine.medical_specialty
Angiogenesis
medicine.drug_class
Hypertension
Pulmonary
Science
030204 cardiovascular system & hematology
Gastroenterology
Article
Angiopoietin
Angiopoietin-2
03 medical and health sciences
Idiopathic pulmonary fibrosis
Prognostic markers
0302 clinical medicine
Internal medicine
medicine
Natriuretic peptide
Angiopoietin-1
Humans
Aged
Proportional Hazards Models
Retrospective Studies
Aged
80 and over
Multidisciplinary
Lung
business.industry
Endothelial Cells
Diagnostic markers
Middle Aged
medicine.disease
Prognosis
Pulmonary hypertension
Idiopathic Pulmonary Fibrosis
medicine.anatomical_structure
Treatment Outcome
030228 respiratory system
Gene Expression Regulation
Case-Control Studies
Vascular resistance
Immunohistochemistry
Medicine
Female
Vascular Resistance
business
Biomarkers
Zdroj: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
ISSN: 2045-2322
Popis: Several biomarkers for detecting pulmonary hypertension (PH) have been reported. However, these biomarkers are deemed insufficient to detect PH in its early stages. We evaluated the utility of serum angiopoietin (ANGP), a glycoprotein related to angiogenesis, as a diagnostic and prognostic biomarker of PH. Patients with PH who underwent right-heart catheterization, were retrospectively studied. Serum concentrations of ANGP-1 and ANGP-2 were measured using an enzyme-linked immunosorbent assay in patients with PH (n = 32), those with idiopathic pulmonary fibrosis (IPF) without PH (as a disease control, n = 75), and age-matched healthy controls (HC, n = 60). Nineteen patients (59.4%) with PH had World Health Organization group 3 PH. Serum ANGP-2 concentration, but not ANGP-1, in patients with PH was significantly higher compared with that in HC (p = 0.025) and in patients with IPF without PH (p = 0.008). Serum ANGP-2 concentration in patients with PH positively and significantly correlated with N-terminal pro-B-type natriuretic peptide (r = 0.769, p
Databáze: OpenAIRE
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