Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension
Autor: | Naoki Inui, Hironao Hozumi, Hiroshi Watanabe, Noriyuki Enomoto, Masato Maekawa, Takamichi Ishikawa, Kensuke Kataoka, Seiichiro Suzuki, Yasuhiro Kondoh, Keiichi Odagiri, Takafumi Suda, Masato Karayama, Tomoyuki Fujisawa, Kazuki Furuhashi, Yuzo Suzuki, Yutaro Nakamura |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Adult
Male medicine.medical_specialty Angiogenesis medicine.drug_class Hypertension Pulmonary Science 030204 cardiovascular system & hematology Gastroenterology Article Angiopoietin Angiopoietin-2 03 medical and health sciences Idiopathic pulmonary fibrosis Prognostic markers 0302 clinical medicine Internal medicine medicine Natriuretic peptide Angiopoietin-1 Humans Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Multidisciplinary Lung business.industry Endothelial Cells Diagnostic markers Middle Aged medicine.disease Prognosis Pulmonary hypertension Idiopathic Pulmonary Fibrosis medicine.anatomical_structure Treatment Outcome 030228 respiratory system Gene Expression Regulation Case-Control Studies Vascular resistance Immunohistochemistry Medicine Female Vascular Resistance business Biomarkers |
Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Several biomarkers for detecting pulmonary hypertension (PH) have been reported. However, these biomarkers are deemed insufficient to detect PH in its early stages. We evaluated the utility of serum angiopoietin (ANGP), a glycoprotein related to angiogenesis, as a diagnostic and prognostic biomarker of PH. Patients with PH who underwent right-heart catheterization, were retrospectively studied. Serum concentrations of ANGP-1 and ANGP-2 were measured using an enzyme-linked immunosorbent assay in patients with PH (n = 32), those with idiopathic pulmonary fibrosis (IPF) without PH (as a disease control, n = 75), and age-matched healthy controls (HC, n = 60). Nineteen patients (59.4%) with PH had World Health Organization group 3 PH. Serum ANGP-2 concentration, but not ANGP-1, in patients with PH was significantly higher compared with that in HC (p = 0.025) and in patients with IPF without PH (p = 0.008). Serum ANGP-2 concentration in patients with PH positively and significantly correlated with N-terminal pro-B-type natriuretic peptide (r = 0.769, p |
Databáze: | OpenAIRE |
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