Dietary beta-carotene inhibits mammary carcinogenesis in rats depending on dietary alpha-linolenic acid content

Autor: Marie-Lise Jourdan, Claude Hoinard, Veronique Chajes, Khelifa Arab, Philippe Bougnoux, Virginie Maillard
Přispěvatelé: Nutrition, croissance et cancer (U 1069) (N2C), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Tours (UT), Fed. Biochimie, Hospices Civils de Lyon (HCL)-Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Génétique oncologique (GO - UMR 8125), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2006
Předmět:
medicine.medical_treatment
mammary tumours
Medicine (miscellaneous)
MESH: Dietary Supplements
MESH: Rats
Sprague-Dawley
Antioxidants
S Phase
Rats
Sprague-Dawley
chemistry.chemical_compound
Mammary tumorigenesis
MESH: Animals
Nutrition and Dietetics
Fatty Acids
Carotene
MESH: S Phase
food and beverages
beta Carotene
Malondialdehyde
MESH: Fatty Acids
alpha-linolenic acid
beta-carotene
Adipose Tissue
MESH: beta Carotene
Mammary carcinogenesis
MESH: Cell Division
Female
Cell Division
MESH: Adipose Tissue
medicine.medical_specialty
MESH: alpha-Linolenic Acid
MESH: Rats
Linolenic acid
Linoleic acid
MESH: Mammary Neoplasms
Experimental
[SDV.CAN]Life Sciences [q-bio]/Cancer
Biology
Article
ω-6/ω-3 fatty acid ratio
MESH: Diet
Internal medicine
medicine
Animals
α-linolenic acid
Fatty Acids
Essential
Cell growth
MESH: Antioxidants
Mammary Neoplasms
Experimental
Diet
Rats
Endocrinology
chemistry
MESH: Fatty Acids
Essential
Dietary Supplements
MESH: Female
Zdroj: British Journal of Nutrition
British Journal of Nutrition, Cambridge University Press (CUP), 2006, 96 (1), pp.18-21
ISSN: 0007-1145
1475-2662
Popis: To investigate whether dietary alpha-linolenic acid (ALA) content alters the effect of beta-carotene on mammary carcinogenesis, we conducted a chemically induced mammary tumorigenesis experiment in rats randomly assigned to four nutritional groups (15 rats per group) varying in beta-carotene supplementation and ALA content. Two oil formula-enriched diets (15 %) were used: one with 6 g ALA/kg diet in an essential fatty acids (EFA) ratio of linoleic acid:ALA of 5:1 w/w (EFA 5 diet), the other with 24 g ALA/kg diet in an EFA ratio of 1:1 w/w (EFA 1 diet), both designed with a similar linoleic acid content. beta-Carotene was either added (10 mg/kg diet per d) or not added to these diets. beta-Carotene supplementation led to decreased tumour incidence and tumour growth when added to the EFA 5 diet, whereas it had no effect when added to the EFA 1 diet. The decreased tumour growth did not result from an involvement of lipoperoxidation (tumour malondialdehyde content being similar between the groups) or from an inhibition of tumour cell proliferation (as there was an unchanged S phase fraction in the tumours). We concluded that an adequate content of ALA in the diet is required to allow a protective effect of beta-carotene in mammary carcinogenesis. Whether such an interaction between ALA and beta-carotene influences the risk of breast cancer in women needs to be investigated.
Databáze: OpenAIRE
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