Genotype-phenotype correlations in hepatocellular adenoma: an update of MRI findings
| Autor: | Maarten Thomeer, Jan Nm Ijzermans, Katharina Biermann, Robert A. de Man, Mirelle E.E. Bröker, Marianne de Vries, Roy S. Dwarkasing, Quido de Lussanet |
|---|---|
| Přispěvatelé: | Radiology & Nuclear Medicine, Surgery, Pathology, Gastroenterology & Hepatology |
| Rok vydání: | 2014 |
| Předmět: |
Gadolinium DTPA
Male Pathology medicine.medical_specialty Liver tumor Genotype Adenoma Contrast Media Gadolinium Malignancy Adenoma Liver Cell Diagnosis Differential Gadoxetate Disodium Young Adult medicine Humans Abdominal Imaging Radiology Nuclear Medicine and imaging Pathological beta Catenin medicine.diagnostic_test business.industry Liver Neoplasms Focal nodular hyperplasia Magnetic resonance imaging Middle Aged Hepatocellular adenoma Image Enhancement medicine.disease Immunohistochemistry Magnetic Resonance Imaging Phenotype Liver Focal Nodular Hyperplasia Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Diagnostic and Interventional Radiology, 20(3), 193-199. Turkish Society of Radiology |
| ISSN: | 1305-3612 1305-3825 |
| DOI: | 10.5152/dir.2013.13315 |
| Popis: | Hepatocellular adenoma (HCA) is a generally benign liver tumor with the potential for malignancy and bleeding. HCAs are categorized into four subtypes on the basis of genetic and pathological features: hepatocyte nuclear factor 1 alpha-mutated HCA, beta-catenin-mutated HCA, inflammatory HCA, and unclassified HCA. Magnetic resonance imaging (MRI) plays an important role in the diagnosis, subtype characterization, and detection of HCA complications; it is also used to differentiate HCA from focal nodular hyperplasia. In this review, we present an overview of the genetic abnormalities, oncogenesis, and typical and atypical MRI findings of specific subtypes of HCA using contrast-enhanced MRI with or without hepatobiliary contrast agents (gadobenate dimeglumine and gadoxetate disodium). We also discuss their different management implications after diagnosis. |
| Databáze: | OpenAIRE |
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