CHRONIC CHAGAS’ DISEASE IN RHESUS MONKEYS (MACACA MULATTA): EVALUATION OF PARASITEMIA, SEROLOGY, ELECTROCARDIOGRAPHY, ECHOCARDIOGRAPHY, AND RADIOLOGY
| Autor: | Octavio Fernandes, Márcia Cristina Ribeiro Andrade, Joseli Lannes-Vieira, Sérgio Salles Xavier, Ana Maria Jansen, Constança Britto, Maria da Gloria Bonecini-Almeida, R. H. Mangia, Cristiano Marcelo Espinola Carvalho |
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| Rok vydání: | 2003 |
| Předmět: |
Chagas Cardiomyopathy
Male Chagas disease Trypanosoma cruzi Cardiomyopathy Antibodies Protozoan Parasitemia Polymerase Chain Reaction Serology Electrocardiography Virology parasitic diseases medicine Animals Humans Chagas Disease biology business.industry medicine.disease biology.organism_classification Macaca mulatta Radiography Disease Models Animal Infectious Diseases Echocardiography Immunoglobulin G Chronic Disease Immunology biology.protein Parasitology Antibody business Trypanosomiasis Xenodiagnosis |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 68:683-691 |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | Severe chronic damage to the heart and gastrointestinal tract in patients with Chagas' disease are often observed 10-20 years after the acute phase. The course of long-lasting infection with the Colombian strain of Trypanosoma cruzi was studied in seven rhesus monkeys infected for 15-19 years. Subpatent parasitemia was detected in all studied animals, using hemoculture (two of seven), artificial xenodiagnosis (three of seven), and a polymerase chain reaction PCR (six of six). High titers of specific IgG antibody to T. cruzi persisted throughout the chronic phase of infection. Abnormal electrocardiographic (three of six) and echocardiographic (one of six) patterns detected in the T. cruzi-infected monkeys were possibly related to parasite-triggered myocardial damage. The results suggest that rhesus monkeys experimentally infected with T. cruzi, besides reproducing the acute phase of Chagas' disease, also develop chronic chagasic cardiomyopathy. |
| Databáze: | OpenAIRE |
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