Synthesis and SAR of a Novel Positive Allosteric Modulator (PAM) of the Metabotropic Glutamate Receptor 4 (mGluR4)

Autor:	Craig W. Lindsley, Richard Williams, Kari A. Johnson, Colleen M. Niswender, P. Jeffrey Conn, Corey R. Hopkins, Patrick R. Gentry, Charles David Weaver
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	Allosteric modulator Cyclohexanecarboxylic Acids Clinical Biochemistry Allosteric regulation Pharmaceutical Science Receptors Metabotropic Glutamate Biochemistry Chemical synthesis Article Structure-Activity Relationship Allosteric Regulation In vivo Drug Discovery Structure–activity relationship Animals Anilides Molecular Biology Chemistry Metabotropic glutamate receptor 4 Organic Chemistry Parkinson Disease Ligand (biochemistry) Rats Disease Models Animal Metabotropic receptor Biophysics Molecular Medicine Allosteric Site
Popis:	This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80334d235a2b4088df721f8c2e8e2e1c https://europepmc.org/articles/PMC2752865/ Zobrazit plný text záznamu