Neonates colonized with pathogenic bacteria in the airways have a low-grade systemic inflammation
| Autor: | Jakob Stokholm, Karen A. Krogfelt, Susanne Brix, Hans Bisgaard, Bo L. Chawes, N. Rahman Fink, Susanne Schjørring, Marie Kragh, Klaus Bønnelykke, Jonathan Thorsen |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Denmark Environment and hygiene hypothesis Respiratory System Immunology Clinical immunology medicine.disease_cause Systemic inflammation Pediatrics Gastroenterology Asymptomatic Haemophilus influenzae 03 medical and health sciences 0302 clinical medicine Internal medicine Streptococcus pneumoniae medicine Humans Immunology and Allergy 030212 general & internal medicine Prospective cohort study Respiratory Tract Infections Moraxella Asthma Innate immunity Inflammation Bacteriological Techniques biology business.industry Age Factors Infant Newborn Infant Pathogenic bacteria Bacterial Infections medicine.disease biology.organism_classification 030228 respiratory system Female medicine.symptom business Biomarkers |
| Zdroj: | Rahman Fink, N, Chawes, B L, Thorsen, J, Stokholm, J, Krogfelt, K, Schjørring, S, Kragh, M, Bønnelykke, K, Brix, S & Bisgaard, H 2018, ' Neonates colonized with pathogenic bacteria in the airways have a low-grade systemic inflammation ', Allergy, vol. 73, no. 11, pp. 2150-2159 . https://doi.org/10.1111/all.13461 |
| ISSN: | 0105-4538 |
| DOI: | 10.1111/all.13461 |
| Popis: | BACKGROUND AND OBJECTIVES The development of childhood asthma is associated with neonatal colonization with pathogenic bacteria in hypopharynx. Furthermore, established asthma is associated with systemic low-grade inflammation. We here report on the association between neonatal colonization with pathogenic bacteria in hypopharynx and the development of systemic low-grade inflammation. METHODS Bacterial colonization of the hypopharynx with Moraxella catharralis, Haemophilus influenzae, and/or Streptococcus pneumoniae was assessed in asymptomatic children from the Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000 ) cohort at age 1 month by culturing technique (N = 238) and by quantitative polymerase chain reaction (qPCR) technique (N = 249) and in the COPSAC2010 cohort by culturing at age 1 month (N = 622) and again at age 3 months (N = 613). Systemic low-grade inflammation was determined in both cohorts at age 6 months by measuring plasma levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (lL-6). RESULTS In both cohorts, bacterial colonization was associated with increased levels of hs-CRP: COPSAC2000 , 1 month culturing (geometric mean ratio of colonized/noncolonized [95% CI]), 1.39 [0.97-2.01], P = .08; 1 month qPCR, 1.55 [1.14-2.10], P < .01; COPSAC2010 , 1 month, 1.52 [1.23-1.87], P < .01; and 3 month, 1.57 [1.30-1.90], P < .01. A multiparametric principal component analysis incorporating hs-CRP, TNF-α, and IL-6 confirmed a systemic inflammatory profile in children colonized with M. catharralis, H. influenzae. and/or S. pneumoniae in the hypopharynx compared to noncolonized children (P-values < .05). CONCLUSION The composition of the upper airway microbiome in early life may cause systemic low-grade inflammation. |
| Databáze: | OpenAIRE |
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