Complex Effects of Antibodies to Polypeptide Hormones
| Autor: | Marion E. Webster, Joseph S. McGUIRE, Theodore L. Goodfriend |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
medicine.medical_specialty
Melanocyte-stimulating hormone Endocrinology Diabetes and Metabolism Clinical Biochemistry Radioimmunoassay Blood Pressure In Vitro Techniques Peptide hormone Biology Bradykinin Biochemistry Antibodies Antigen-Antibody Reactions Endocrinology Ileum Internal medicine medicine Animals Protease Inhibitors Melanocyte-Stimulating Hormones Receptor Inflammation Catabolism Angiotensin II Uterus Biochemistry (medical) Muscle Smooth Rats Hypertension biology.protein Melanocytes Biological Assay Female Rabbits gamma-Globulins Antibody Peptides Hormone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 30:565-572 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Rabbit antibodies to bradykinin and α-MSH prolong the effects of these hormones in some assay systems. Evidence is presented to show that the prolongation results from protection by antibody against degradation of the hormones. Under some assay conditions, and at high concentrations, antibodies to α-MSH inhibit the skin-darkening effect of the hormone. Antibodies to angiotensin II inhibit its action on some targets while they protect it from enzymatic degradation. The variable effects of antibodies to hormones appear to depend on several factors, including the relative quantities and affinities of antibody, degradative pathways, and receptors. |
| Databáze: | OpenAIRE |
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