Metabolic Alterations in Older Women With Low Bone Mineral Density Supplemented With Lactobacillus reuteri

Autor: Ling Qun Ye, Boyang Ji, Mattias Lorentzon, Dimitra Lappa, Daniel Sundh, Peishun Li, Jens Nielsen
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: JBMR Plus, Vol 5, Iss 4, Pp n/a-n/a (2021)
Li, P, Sundh, D, Ji, B, Lappa, D, Ye, L, Nielsen, J & Lorentzon, M 2021, ' Metabolic Alterations in Older Women With Low Bone Mineral Density Supplemented With Lactobacillus reuteri ', JBMR Plus, vol. 5, no. 4, e10478 . https://doi.org/10.1002/jbm4.10478
ISSN: 2473-4039
DOI: 10.1002/jbm4.10478
Popis: JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research. Osteoporosis and its associated fractures are highly prevalent in older women. Recent studies have shown that gut microbiota play important roles in regulating bone metabolism. A previous randomized controlled trial (RCT) found that supplementation with Lactobacillus reuteri ATCC PTA 6475 (L.reuteri) led to substantially reduced bone loss in older women with low BMD. However, the total metabolic effects of L. reuteri supplementation on older women are still not clear. In this study, a post hoc analysis (not predefined) of serum metabolomic profiles of older women from the previous RCT was performed to investigate the metabolic dynamics over 1 year and to evaluate the effects of L. reuteri supplementation on human metabolism. Distinct segregation of the L. reuteri and placebo groups in response to the treatment was revealed by partial least squares-discriminant analysis. Although no individual metabolite was differentially and significantly associated with treatment after correction for multiple testing, 97 metabolites responded differentially at any one time point between L. reuteri and placebo groups (variable importance in projection score >1 and p value
Databáze: OpenAIRE
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