Structural characterization of microcrystalline and nanocrystalline cellulose from Ananas comosus L. leaves: Cytocompatibility and molecular docking studies
| Autor: | Nursyazwani Shadan, Mahboob Alam, Muhammad Hanif Sainorudin, Nur Athirah Abdullah, Nurul Huda Abd Kadir, Masita Mohammad, Munirah Mahizan, Mohd Saiful Asmal Rani, A. El-Denglawey, Zahira Yaakob |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
ncc
mcc Technology Physical and theoretical chemistry QD450-801 Energy Engineering and Power Technology Medicine (miscellaneous) TP1-1185 Biomaterials chemistry.chemical_compound Cellulose Ananas biology Process Chemistry and Technology Chemical technology molecular docking biology.organism_classification Nanocrystalline material Surfaces Coatings and Films Characterization (materials science) Microcrystalline chemistry pineapple leaves cytotoxicity Biotechnology Nuclear chemistry |
| Zdroj: | Nanotechnology Reviews, Vol 10, Iss 1, Pp 793-806 (2021) |
| ISSN: | 2191-9097 |
| Popis: | The present study focused on the preparation of microcrystalline cellulose (MCC) and nanocrystalline cellulose (NCC) from pineapple (Ananas comosus L.) leaves using chemical treatments followed by acid hydrolysis. Pineapple leaves could be used in medical applications such as drug delivery carriers. Advanced spectroscopy techniques such as Fourier-transform infrared (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) were used to analyze the physical, chemical, and morphological features of the isolated MCC and NCC; the results indicated the needle-shaped form of nanostructures with good purity and high crystallinity index of 75.00 and 76.38%, respectively. In addition, inhibition of the treated MRC-5 cells with all the samples revealed that the percentage of cell viability was less than 30%, which is an interesting finding given their role in the cytotoxicity effect of MCC and NCC. It appears that MCC and NCC derived from pineapple leaves have lower toxicity. As a result, the developed MCC and NCC can be used in pharmaceutical applications as a novel drug delivery system. Molecular docking was performed to understand the non-bonding interaction of cellulose with human acid-beta-glucosidase (β-Glc) (PDB: 1OGS). The docking result shows that cellulose unit docked within the active pocket of the enzyme by forming hydrogen bonds against ASN19, THR21, and VAL17 with distances of 2.18, 1.93, and 2.92 Å, respectively, with binding energy (−5.0 kcal/mol) resulting in close interaction of cellulose unit with the receptor. |
| Databáze: | OpenAIRE |
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