Antiplatelet Activity of Natural Bioactive Extracts from Mango (Mangifera Indica L.) and its By-Products
| Autor: | Eduardo Fuentes, Antonio Segura-Carretero, David Arráez-Román, Lyanne Rodríguez, Iván Palomo, M.E. Alañón |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Physiology Clinical Biochemistry By-products engineering.material Biochemistry Husk Bioactive compounds 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology Glucoside Antiplatelet activity antiplatelet activity HPLC-DAD-q-TOF-MS Mangifera Food science Mangiferin Molecular Biology Inhibitory effect by-products Mango 030109 nutrition & dietetics bioactive compounds Chemistry Pulp (paper) lcsh:RM1-950 food and beverages 04 agricultural and veterinary sciences Cell Biology 040401 food science lcsh:Therapeutics. Pharmacology engineering Composition (visual arts) Ellagic acid |
| Zdroj: | Antioxidants Volume 8 Issue 11 Digibug. Repositorio Institucional de la Universidad de Granada instname Antioxidants, Vol 8, Iss 11, p 517 (2019) |
| Popis: | The potential antiplatelet aggregation effects of mango pulp and its by-products (peel, husk seed, and seed) due to the presence of bioactive compounds were explored. Among them, mango seed exhibited a 72% percentage inhibition of platelet aggregation induced by adenosine 5’-diphosphate (ADP) agonist with a demonstrated dose-dependent effect. This biological feature could be caused by the chemical differences in phenolic composition. Mango seed was especially rich in monogalloyl compounds, tetra- and penta-galloylglucose, ellagic acid, mangiferin, and benzophenones such as maclurin derivatives and iriflophenone glucoside. Mangiferin showed an inhibitory effect of 31%, suggesting its key role as one of the main contributors to the antiplatelet activity of mango seed. Therefore, mango seed could be postulated as a natural source of bioactive compounds with antiplatelet properties to design functional foods or complementary therapeutic treatments. Ibero-American Program of Science and Technology for Development, Red iberoamericana de aprovechamiento integral de alimentos autóctonos subutilizados (ALSUB-CYTED, 118RT0543). Financial support of projects from program of aid for R + D + i of the Andalusian plan for research, development and innovation (PAIDI 2020) of Junta de Andalucía and Junta de Comunidades de Castilla-La Mancha (SBPLY/17/180501/000509). |
| Databáze: | OpenAIRE |
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