Long-term studies of hemoglobin-oxygen affinity in hypoxemic dogs with a right-to-left cardiac shunt
| Autor: | William F. Skogen, S. Bert Litwin, Amnon Rosenthal, Myron B. Laver |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Time Factors Oxygen affinity Inferior vena cava Phosphates Hypoxemia Hemoglobins Dogs Chronic hypoxemia Internal medicine Animals Medicine Hypoxia business.industry Cardiac shunt Arteries Diphosphoglyceric Acids Adaptation Physiological Oxygen medicine.anatomical_structure medicine.vein Oxyhemoglobins Anesthesia Lactates cardiovascular system Cardiology Right atrium Surgery Hemoglobin medicine.symptom business Ligation |
| Zdroj: | Journal of Surgical Research. 28:118-123 |
| ISSN: | 0022-4804 |
| DOI: | 10.1016/0022-4804(80)90154-7 |
| Popis: | Long-standing hypoxemia was surgically created in dogs by inserting an aortic homograft between the inferior vena cava and right atrium. Ligation of the caval-atria1 junction resulted in a right-toleft cardiac shunt. Arterial p 0, fell immediately and P,, increased within 20 min. The 2,3-diphosphoglycerate concentration rose in 4 hr following surgery, while hemoglobin concentration increased within 7 days. Alterations in hemoglobin-oxygen affinity can occur rapidly and may be beneficial compensatory responses to acute and chronic hypoxemia caused by a right-to-left cardiac shunt. |
| Databáze: | OpenAIRE |
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