Hypoxic vasorelaxation: Ca2+-dependent and Ca2+-independent mechanisms
| Autor: | Richard J. Paul, Yukisato Ishida, George D. Thorne |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Vascular smooth muscle Physiology Chemistry Ryanodine Vasodilation Cell Biology Smooth muscle contraction Hypoxia (medical) Cell Hypoxia Muscle Smooth Vascular Cell biology Internal medicine Cardiology medicine Animals Humans Calcium medicine.symptom Porcine coronary artery Molecular Biology Oxygen sensing |
| Zdroj: | Cell calcium. 36(3-4) |
| ISSN: | 0143-4160 |
| Popis: | The mechanisms of oxygen sensing in vascular smooth muscle have been studied extensively in a variety of tissue types and the results of these studies indicate that the mechanism of hypoxia-induced vasodilation probably involves several mechanisms that combined to assure the appropriate response. After a short discussion of the regulatory mechanisms for smooth muscle contractility, we present the evidence indicating that hypoxic vasorelaxation involves both Ca2+-dependent and Ca2+-independent mechanisms. More recent experiments using proteomic approaches in organ cultures of porcine coronary artery reveal important changes evoked by hypoxia in both Ca2+-dependent and Ca2+-independent pathways. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect