Patients with inflammatory rheumatic diseases
| Autor: | Michael T. Nurmohamed, Karin M Spijkers, Bart J F van den Bemt, Victor J. B. Huiskes, Naomi T Jessurun, L. Kosse, Renske C. F. Hebing |
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| Přispěvatelé: | AII - Inflammatory diseases, ACS - Atherosclerosis & ischemic syndromes, Rheumatology |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Combination therapy Population Disease 030226 pharmacology & pharmacy Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center 0302 clinical medicine Rheumatology Internal medicine Rheumatic Diseases Medicine Humans Pharmacology (medical) 030212 general & internal medicine Prospective Studies Medical prescription Prospective cohort study education Retrospective Studies education.field_of_study Biological Products business.industry Middle Aged Missing data Exact test lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] Antirheumatic Agents Female Self Report business Kappa |
| Zdroj: | Kosse, L J, Jessurun, N T, Hebing, R C F, Huiskes, V J B, Spijkers, K M, van den Bemt, B J F & Nurmohamed, M T 2020, ' Patients with inflammatory rheumatic diseases : quality of self-reported medical information in a prospective cohort event monitoring system ', Rheumatology (Oxford, England), vol. 59, no. 6, pp. 1253-1261 . https://doi.org/10.1093/rheumatology/kez412 Rheumatology (Oxford, England), 59(6), 1253-1261. Oxford University Press Rheumatology, 59, 1253-1261 Rheumatology, 59, 6, pp. 1253-1261 |
| ISSN: | 1462-0324 |
| DOI: | 10.1093/rheumatology/kez412 |
| Popis: | Objectives Assessment of the quality of patient-reported medical information in the Dutch Biologic Monitor and evaluation of the representativeness of the sampled participants. Methods Consecutive adult patients using a biologic DMARD (bDMARD) for an immune-mediated inflammatory disease were included in eight Dutch centres. For this substudy, data of 550 patients with inflammatory rheumatic diseases were used. Patient-reported bDMARD prescription, indication and combination therapy were verified for patients that permitted access to their electronic health record using percentage agreement and/or Cohen’s kappa (n = 483). Conservative post hoc sensitivity analysis was performed to account for missing data. Population representativeness was tested for the entire substudy population by comparing age, gender and prescribed bDMARD to the centres’ reference populations using Mann–Whitney U-test, χ2 goodness-of-fit or Fisher’s exact test with Monte Carlo simulation (n = 550). Results The correct bDMARD was reported by 95.8% of the participants. Agreement between patients and electronic health record was almost perfect for indications (κ = 0.832) and substantial for combination therapies (κ = 0.725). Agreement on combination therapies remained substantial after post hoc sensitivity analysis (κ = 0.640). Gender distribution (P > 0.05) and bDMARD use (P > 0.05) were similar to the reference populations. Median age was different (58.0 vs 56.0 years, P = 0.04), but considered clinically irrelevant. Conclusion The Dutch Biologic Monitor seems to be a valid tool to obtain patient-reported medical information. Reported medical information generally corresponded to the electronic health records and the participants represented their reference populations regarding age, gender and prescribed bDMARD. |
| Databáze: | OpenAIRE |
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