Sex Differences in the Incidence and Outcomes of COPD Patients Hospitalized with Ischemic Stroke in Spain: A Population-Based Observational Study
| Autor: | Rodrigo Jiménez-García, Isabel Jiménez-Trujillo, Marta Lopez-Herranz, Javier de Miguel-Díez, Zichen Ji, Ana López-de-Andrés, José María de Miguel-Yanes, Valentín Hernández-Barrera |
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| Rok vydání: | 2021 |
| Předmět: |
Male
sex differences medicine.medical_specialty Copd patients medicine.medical_treatment Population based International Journal of Chronic Obstructive Pulmonary Disease Brain Ischemia Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine ischemic stroke Humans COPD Medicine Hospital Mortality 030212 general & internal medicine Retrospective Studies Original Research Mechanical ventilation Sex Characteristics business.industry Incidence Incidence (epidemiology) Hospital discharge database General Medicine medicine.disease respiratory tract diseases Hospitalization Stroke 030228 respiratory system Spain Ischemic stroke Female Observational study business in-hospital mortality |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 |
| DOI: | 10.2147/copd.s311826 |
| Popis: | Javier de Miguel-Díez,1,2 Ana López-de-Andrés,3 Rodrigo Jiménez-García,3 Valentín Hernández-Barrera,4 Isabel Jiménez-Trujillo,4 Zichen Ji,1 José María de Miguel-Yanes,5 Marta López-Herranz6 1Pneumology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain; 2Department of Medicine, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, Spain; 3Department of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, Spain; 4Preventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Universidad Rey Juan Carlos, Madrid, Spain; 5Internal Medicine Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain; 6Faculty of Nursing, Physiotherapy and Podology, Universidad Complutense de Madrid, Madrid, 28040, SpainCorrespondence: Ana López-de-AndrésDepartment of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, Madrid, 28040, SpainTel +91 394 1523Fax +91 394 1524Email anailo04@ucm.esPurpose: To compare the incidence, clinical characteristics and outcomes of patients admitted with ischemic stroke (IS) according to the presence of COPD and sex in Spain (2016– 2018).Patients and Methods: We selected all admissions with IS (≥ 35 years) included in the Spanish National Hospital Discharge Database. We matched each patient suffering COPD with a non-COPD patient with identical age, sex, IS type and year of hospitalization.Results: IS was coded in 92,524 men and 79,731 women (8.67% with COPD). The incidence of IS was higher in COPD men than in non-COPD men (IRR 1.04; 95% CI 1.03– 1.06), although the differences were not significant among women. COPD men had twice higher incidence of IS than COPD women (IRR 2.00; 95% CI 1.93– 2.07). After matching, COPD men had a higher in-hospital mortality (IHM) than non-COPD men (11.48% vs 9.80%; p< 0.001), and the same happened among women (14.09% vs 11.96%; p=0.002). COPD men received thrombolytic therapy less frequently than non-COPD men. For men and women, the risk of dying in the hospital increased with age, some comorbidities and mechanical ventilation use. After multivariable adjustment, COPD increased the risk of IHM in men (OR 1.16; 95% CI 1.06– 1.28) and women (OR 1.12; 95% CI 1.01– 1.27). Finally, among COPD patients, being women increased the risk of dying during the hospitalization with IS by 15% (OR 1.15; 95% CI 1.03– 1.28).Conclusion: Incidence of IS was higher in COPD patients, although the difference was only significant for men. COPD was associated with an increased risk of IHM. Among COPD patients, women had higher IHM.Keywords: ischemic stroke, COPD, sex differences, incidence, in-hospital mortality, Spain |
| Databáze: | OpenAIRE |
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