Targeted HIV testing at birth supported by low and predictable mother‐to‐child transmission risk in Botswana
| Autor: | Chloe Auletta-Young, Patrick Jean-Philippe, Daniel R. Kuritzkes, Sikhulile Moyo, Kenneth Maswabi, Xu G. Yu, Roger L. Shapiro, Joseph Makhema, Oganne Batlang, Shahin Lockman, Gbolahan Ajibola, Maryanne Ibrahim, Michael Hughes, Laura Vaughan, Matthias Lichterfeld, Maureen Sakoi |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Risk 0301 basic medicine viral suppression medicine.medical_specialty Mother to child transmission Human immunodeficiency virus (HIV) HIV Infections Hiv testing medicine.disease_cause paediatrics 03 medical and health sciences Zidovudine 0302 clinical medicine children Pregnancy medicine Humans 030212 general & internal medicine Pregnancy Complications Infectious Research Articles Botswana Transmission (medicine) Obstetrics business.industry Infant Newborn Public Health Environmental and Occupational Health HIV virus diseases Gestational age medicine.disease 030112 virology mother‐to‐child transmission Infectious Disease Transmission Vertical Infectious Diseases In utero vertical transmission Female Dried Blood Spot Testing business Research Article medicine.drug |
| Zdroj: | Journal of the International AIDS Society |
| ISSN: | 1758-2652 |
| Popis: | Introduction Most African countries perform infant HIV testing at 6 weeks or later. The addition of targeted testing at birth may improve retention in care, treatment outcomes and survival for HIV‐infected infants. Methods HIV‐exposed infants were screened as part of the Early Infant Treatment (EIT) study in Botswana. Screened infants were ≥35 weeks gestational age and ≥2000 g at birth. Risk factors for mother‐to‐child transmission (MTCT) were assessed by maternal obstetric card or verbally. Risk factors included 400 copies/mL, poor maternal ART adherence, lack of maternal zidovudine (ZDV) in labour, or lack of infant post‐exposure prophylaxis. Infants underwent dried blood spot testing by Roche Cobas Ampliprep/Cobas Taqman HIV‐1 qualitative PCR. Results From April 2015 to April 2016, 2303 HIV‐exposed infants were tested for HIV in the EIT study. Of these, 369 (16%) were identified as high risk for HIV infection by information available at birth, and 12 (0.5% overall, 3.25% of high risk) were identified as HIV positive at birth. All 12 positive infants were identified as high risk at the time of screening, and only 2 risk factors were required to identify all positive infants: either |
| Databáze: | OpenAIRE |
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