Feeding differences in pubertal and aged golden hamsters (Mesocricetus auratus) are related to specific cerebral expression pattern of histamine subtype 3 receptor
| Autor: | Maria Madeo, Sandro Tripepi, Rosa Maria Facciolo, Teresa Granata, Marcello Canonaco |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Aging medicine.medical_specialty Central nervous system Drinking Hamster Tritium Amygdala Eating Behavioral Neuroscience Histamine receptor chemistry.chemical_compound Microscopy Electron Transmission Cricetinae Internal medicine medicine Animals Receptors Histamine H3 In Situ Hybridization Analysis of Variance Thioperamide Behavior Animal Dose-Response Relationship Drug Mesocricetus biology Age Factors Brain Gene Expression Regulation Developmental Feeding Behavior biology.organism_classification Endocrinology medicine.anatomical_structure Animals Newborn chemistry Histamine H1 Antagonists Neuroscience Histamine Protein Binding medicine.drug Golden hamster |
| Zdroj: | Behavioral Neuroscience. 120:1235-1241 |
| ISSN: | 1939-0084 0735-7044 |
| DOI: | 10.1037/0735-7044.120.6.1235 |
| Popis: | The hibernating golden hamster (Mesocricetus auratus) is becoming a useful rodent model to study the neurophysiological role of some neuromediators on vital behaviors such as sleep and thermoregulation. Recent works have shown that the histamine neuroreceptor subtypes (H-sub(1-3)R) are able to modulate such behaviors. Here, specific subtype(s) and cerebral nuclei that were actively operating on feeding behaviors in pubertal and adult hamsters were identified. Of the subtypes assessed, H-sub-3R antagonist (thioperamide) provoked significant (p < .001) changes in behavior (very low total food and water intake) in adults, whereas it did not significantly modify these behaviors in pubertals. The H-sub-3R antagonist's role seemed to be related to elevated amounts of stress-induced damaged neurons displaying, mainly, shrunken crenated cell membranes and altered synaptic processes in limbic areas such as amygdala, cortex, and hippocampus. At the transcription level, an evident expression pattern of H-sub-3R messenger RNA appeared in pubertals, especially in neurons of the cortex and hippocampus, whereas the same trend was featured in amygdalar areas of hibernating adult hamsters, suggesting early H-sub-3R regulatory activities, at least in limbic sites of this rodent model. |
| Databáze: | OpenAIRE |
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