Effect of antiresorptive drugs in the alveolar bone healing. A histometric and immunohistochemical study in ovariectomized rats
| Autor: | Roberta Okamoto, Gustavo Antonio Correa Momesso, Igor de Oliveira Puttini, Gabriel Ramalho-Ferreira, Leonardo Perez Faverani, Eloá Rodrigues Luvizuto |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2016 |
| Předmět: |
endocrine system
medicine.medical_specialty Ovariectomy Osteocalcin 030209 endocrinology & metabolism 01 natural sciences 010309 optics 03 medical and health sciences 0302 clinical medicine Osteoprotegerin Osteogenesis Internal medicine 0103 physical sciences Alveolar Process medicine Animals Raloxifene Rats Wistar General Dentistry Immature Bone Dental alveolus Wound Healing Bone Density Conservation Agents Alendronate biology Tartrate-Resistant Acid Phosphatase business.industry RANK Ligand RANKL Immunohistochemistry Rats surgical procedures operative Endocrinology Raloxifene Hydrochloride biology.protein Ovariectomized rat Female business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 1436-3771 1432-6981 |
| Popis: | Made available in DSpace on 2018-12-11T17:04:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-06-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objectives: The aim of this study is to evaluate the alendronate and raloxifene influence in the alveolar healing process of osteoporotic rats. Materials and methods: Sixty-four female rats were divided in four groups: sham rats (SHAM), ovariectomized rats and no medical treatment (OVX NT), ovariectomized rats and submitted to alendronate treatment (OVX ALE), and ovariectomized and submitted to raloxifene treatment (OVX RAL). The histomorphometrical and immunohistochemical analysis was performed. The quantitative data were analyzed through Kruskal-Wallis and Dunn tests (α = 0.05). Results: In the longest period, SHAM and OVX RAL groups showed the better bone formation responses (P |
| Databáze: | OpenAIRE |
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