Meso-substituted cationic 3- and 4-N-Pyridylporphyrins and their Zn(II) derivatives for antibacterial photodynamic therapy
| Autor: | Valery V. Tuchin, Karapet R. Ghazaryan, Anna G. Gyulkhandanyan, Grigor V. Gyulkhandanyan, Marina H. Paronyan, Ekaterina N. Lazareva, Elena S. Tuchina, Maria V. Korchenova, Boris M. Dzhagarov, Marina V. Parkhats, Aram G. Gyulkhandanyan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Technology
Microorganism medicine.medical_treatment Biomedical Engineering сальмонелла тифимуриум Medicine (miscellaneous) Photodynamic therapy antibacterial photodynamic therapy катионные порфирины e. coli грамположительные бактерии phototoxicity антибактериальная фотодинамическая терапия cationic porphyrins/metalloporphyrins polycyclic compounds medicine S. золотистый gram negative and gram positive bacteria singlet oxygen quantum yield Pathogenic microorganism Chemistry Cationic polymerization квантовый выход синглетного кислорода QC350-467 грамотрицательные бактерии Optics. Light Combinatorial chemistry фототоксичность Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials s. aureus mrsa zn–metalloporphyrins salmonella typhimurium Phototoxicity металлопорфирины |
| Zdroj: | Journal of innovative optical health sciences. 2022. Vol. 15, № 1. P. 2142007-1-2142007-16 Journal of Innovative Optical Health Sciences, Vol 15, Iss 1, Pp 2142007-1-2142007-16 (2022) |
| Popis: | Photodynamic inactivation of microorganisms known as antibacterial photodynamic therapy (APDT) is one of the most promising and innovative approaches for the destruction of pathogenic microorganisms. Among the photosensitizers (PSs), compounds based on cationic porphyrins/metalloporphyrins are most successfully used to inactivate microorganisms. Series of meso-substituted cationic pyridylporphyrins and metalloporphyrins with various peripheral groups in the third and fourth positions of the pyrrole ring have been synthesized in Armenia. The aim of this work was to determine and test the most effective cationic porphyrins and metalloporphyrins with high photoactivity against Gram negative and Gram positive microorganisms. It was shown that the synthesized cationic pyridylporphyrins/metalloporphyrins exhibit a high degree of phototoxicity towards both types of bacteria, including the methicillin-resistant S. aureus strain. Zinc complexes of porphyrins are more phototoxic than metal-free porphyrin analogs. The effectiveness of these Zn–metalloporphyrins on bacteria is consistent with the level of singlet oxygen generation. It was found that the high antibacterial activity of the studied cationic porphyrins/metalloporphyrins depends on four factors: the presence in the porphyrin macrocycle of a positive charge (+4), a central metal atom (Zn[Formula: see text] and hydrophobic peripheral functional groups as well as high values of quantum yields of singlet oxygen. The results indicate that meso-substituted cationic pyridylporphyrins/metalloporphyrins can find wider application in photoinactivation of bacteria than anionic or neutral PSs usually used in APDT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|