Characterization of monoclonal antibodies directed against trail or trail receptors
| Autor: | John Wijdenes, Brigitte Bonnin, Claudine Vermot-Desroches, Elise Sergent |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Programmed cell death
Necrosis medicine.drug_class Immunology Apoptosis Enzyme-Linked Immunosorbent Assay Biology Monoclonal antibody Receptors Tumor Necrosis Factor Cell Line TNF-Related Apoptosis-Inducing Ligand Osteoprotegerin Antigen Antibody Specificity medicine Humans Leukocyte Differentiation Receptor Membrane Glycoproteins Tumor Necrosis Factor-alpha Antibodies Monoclonal Molecular biology Leukocytes Mononuclear medicine.symptom Apoptosis Regulatory Proteins |
| Zdroj: | Cellular Immunology. 236:86-91 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/j.cellimm.2005.08.012 |
| Popis: | A subset of tumour necrosis factor receptor family members is involved in death transducing signals and is, therefore, referred as the “death receptors.” Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in many tumour cells but only rarely in normal cells. Five distinct receptors have been described for TRAIL: TRAIL R1 (DR4), TRAIL R2 (DR5, TRICK), TRAIL R3 (TRID, DcR1), TRAIL R4 (TRUNDD, DcR2), and osteoprotegerin. In the Eighth International Workshop on Human Leukocyte Differentiation Antigens, 10 monoclonal antibodies (mAbs) reported to be specific for TRAIL or for TRAIL receptors were submitted. In the present study, the mAb specificity was determined by ELISA. Using these mAbs, investigation on the expression of TRAIL and TRAIL receptors was performed. Some of them were able to modulate TRAIL induced programmed cell death. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect