Lack of association between polymorphisms in the CYP1A2 gene and risk of cancer: evidence from meta-analyses
Autor: | Vladimir Vukovic, Rosarita Amore, Emanuele Leoncini, Carolina Ianuale, Stefania Boccia, Roberta Pastorino, Maria Rosaria Gualano |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty European Continental Ancestry Group CYP1A2 Population Single-nucleotide polymorphism Genome-wide association study Polymorphism Single Nucleotide White People 03 medical and health sciences Cancer Meta-analysis Polymorphism Susceptibility Cytochrome P-450 CYP1A2 Genome-Wide Association Study Humans Neoplasms Risk Factors Genetic Predisposition to Disease Genetics 0302 clinical medicine Internal medicine Genetic model medicine education Settore MED/42 - IGIENE GENERALE E APPLICATA Genetic association education.field_of_study Bladder cancer business.industry Single Nucleotide Odds ratio medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis business Research Article |
Zdroj: | BMC Cancer |
ISSN: | 1471-2407 |
DOI: | 10.1186/s12885-016-2096-5 |
Popis: | Polymorphisms in the CYP1A2 genes have the potential to affect the individual capacity to convert pre-carcinogens into carcinogens. With these comprehensive meta-analyses, we aimed to provide a quantitative assessment of the association between the published genetic association studies on CYP1A2 single nucleotide polymorphisms (SNPs) and the risk of cancer. We searched MEDLINE, ISI Web of Science and SCOPUS bibliographic online databases and databases of genome-wide association studies (GWAS). After data extraction, we calculated Odds Ratios (ORs) and 95 % confidence intervals (CIs) for the association between the retrieved CYP1A2 SNPs and cancer. Random effect model was used to calculate the pooled ORs. Begg and Egger tests, one-way sensitivity analysis were performed, when appropriate. We conducted stratified analyses by study design, sample size, ethnicity and tumour site. Seventy case-control studies and one GWA study detailing on six different SNPs were included. Among the 71 included studies, 42 were population-based case-control studies, 28 hospital-based case-control studies and one genome-wide association study, including total of 47,413 cancer cases and 58,546 controls. The meta-analysis of 62 studies on rs762551, reported an OR of 1.03 (95 % CI, 0.96–1.12) for overall cancer (P for heterogeneity |
Databáze: | OpenAIRE |
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