Hypertriglyceridemia in Sars-Cov-2 infected patients treated with parenteral nutrition
| Autor: | L. Santulario-Verdu, M. Fernandez-Alvarez, M. Colls-Gonzalez, M. Muñoz-Bolaño, Elisabet Leiva-Badosa, M. Badia-Tahull, S. Otero-Torres, J. Llop-Talaverón |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics business.industry Endocrinology Diabetes and Metabolism Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Hypertriglyceridemia Lopinavir Clinical nutrition medicine.disease Enteral administration Gastroenterology Article Parenteral nutrition Internal medicine Cohort Medicine business Propofol medicine.drug |
| Zdroj: | Clinical Nutrition ESPEN Clinical Nutrition Espen |
| ISSN: | 2405-4577 |
| Popis: | Rationale: To evaluate hypertriglyceridemia (HTG) risk factors in adult hospitalized COVID patients treated with Parenteral Nutrition (PN) Methods: Patients starting PN from 03/16-04/15/2020 were selected Data collected: demographic, nutritional (indication, days of PN, PN composition (g/kg/d by adjusted body weight);COVID treatments and analytical In our COVID protocol, inflammatory state (IS) was considered with at least 2 of the next criteria: PCR>100mg/L, DD>1 000μ/L, LDH>400U/L, ferritin>1 000ng/ml and IL-6>70ng/L HTG was defined as triglycerides (TG)≥3 mmol/L Data expressed as median [IQR] T-student test to compare our results with a previous no-COVID cohort with PN at our center and TG at PN beginning and end Multivariate analysis to study TG at PN beginning and HTG risk factors Results: 54 patients, 72 2% men, 67 6 [13 4] years, 80 [19 3] kg, 29 8 [5 6] kg/m2, 61 1 % had dyslipidaemia PN lasted 5 [5] days 83 3% received PN for enteral intolerance PN composition (g/kg/d): 1 28 [0 05] nitrogen, 0 57 [0 78] lipids, 3 05 [1 53] glucose and 19 8 [7 1] kcal/kg/d No differences between TGC at PN beginning and ending (3,56 [1 01] vs 3 621[1 74], p: 0 89) 80% met IS, 79 6% critical or semicritical, and 50% died 81 5% received tocilizumab, 79 6% propofol and 12 9% tacrolimus TG before PN started were higher than our previous cohort (3 31[1 14] vs 2 24[1 19] mmol/L;p |
| Databáze: | OpenAIRE |
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