| Autor: |
Kirill Kirsanov, Timur Fetisov, Elena Antoshina, Lubov Trukhanova, Tatiana Gor’kova, Olga Vlasova, Irina Khitrovo, Ekaterina Lesovaya, Nataliya Kulbachevskaya, Tatiana Shcherbakova, Gennady Belitsky, Marianna Yakubovskaya, Vytas Švedas, Dmitry Nilov |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Frontiers in pharmacology. 13 |
| ISSN: |
1663-9812 |
| Popis: |
7-Methylguanine (7-MG) competitively inhibits the DNA repair enzyme poly(ADP-ribose) polymerase (PARP) and RNA-modifying enzyme tRNA-guanine transglycosylase (TGT) and represents a potential anticancer drug candidate. Furthermore, as a natural compound, it could escape the serious side effects characteristic for approved synthetic PARP inhibitors. Here we present a comprehensive study of toxicological and carcinogenic properties of 7-MG. It was demonstrated that 7-MG does not induce mutations or structural chromosomal abnormalities, and has no blastomogenic activity. A treatment regimen with 7-MG has been established in mice (50 mg/kg per os, 3 times per week), exerting no adverse effects or changes in morphology. Preliminary data on the 7-MG anticancer activity obtained on transplantable tumor models support our conclusions that 7-MG can become a promising new component of chemotherapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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