Progesterone induced blocking factor (PIBF) taken in early pregnancy predicts the pregnancy outcome in women undergoing in vitro fertilization procedure
| Autor: | Agnes Bogdan, Helena Ban Frangez, Selmira Brkic, Nina Jančar, Julia Szekeres-Bartho, Igor Hudić, Lejla Mesalic, Irma Virant Klun, Eda Bokal Vrtačnik, Larisa Dizdarevic Hudic |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Infertility medicine.medical_specialty medicine.medical_treatment media_common.quotation_subject Immunology Blocking factor Early pregnancy factor Fertilization in Vitro Urine Pregnancy Proteins Miscarriage 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Pregnancy Suppressor Factors Immunologic medicine Humans Immunology and Allergy Embryo Implantation Ovulation media_common 030219 obstetrics & reproductive medicine In vitro fertilisation biology business.industry Obstetrics Pregnancy Outcome Obstetrics and Gynecology Prognosis medicine.disease 030104 developmental biology Reproductive Medicine biology.protein Female Pregnancy Trimesters business Infertility Female |
| Zdroj: | Journal of Reproductive Immunology. 140:103150 |
| ISSN: | 0165-0378 |
| Popis: | Earlier data suggest a relationship between PIBF concentrations and the outcome of pregnancy. The aim of the study was to compare serum and urine concentrations of PIBF in women with successful pregnancy after IVF with those of women without pregnancy after IVF procedure, and to evaluate the potential relation between PIBF and the outcome of pregnancy. Urine and serum were collected from 120 women, undergoing IVF. 87.5% of patients had primary infertility. 69.2% faced female causes of infertility: 10.8% tubal cause, 11.7% ovulation disorder, and 46.7% other causes of infertility. 30.8% of patients had male factor of infertility. Among non-pregnant women (42) mean concentrations of PIBF in urine and serum were significantly lower (15.8 ng/mL; 148.4 ng/mL) than in women with positive beta HCG value (78) (19.1 ng/mL; 225.9 ng/mL). In 49 patients pregnancy terminated with a term delivery, in 10 patients with pretem delivery, while in 19 patients the pregnancy terminated with a miscarriage. PIBF concentrations in urine (13.9 ± 2.8 ng/mL) and serum (124.6 ± 46.7 ng/mL) samples of women with miscarriage were significantly lower of those with preterm delivery (180.6 ± 54.4 ng/mL; 18.1 ± 4.4 ng/mL) and of those with term delivery (20.4 ± 8.5 ng/mL; 208.7 ± 114.3 ng/mL). Successful pregnancy after IVF procedure is predictable by measuring of urine and serum PIBF concentrations and could be important for predicting of early implantation and pregnancy outcome after IVF procedure and maybe to protect the risk pregnancy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect