Increasing drug resistance of Mycobacterium tuberculosis in Sinaloa, Mexico, 1997–2005
| Autor: | Secundino Muro-Amador, Jorge Zazueta-Beltran, Adrian Canizalez-Roman, Jorge Velazquez-Roman, Nidia León-Sicairos, Héctor Flores-Villaseñor, Adrian Flores-Gaxiola |
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| Rok vydání: | 2011 |
| Předmět: |
Drug
Adult Male Microbiology (medical) medicine.medical_specialty Tuberculosis Adolescent media_common.quotation_subject Antitubercular Agents Drug resistance Microbial Sensitivity Tests World health Mycobacterium tuberculosis Young Adult Internal medicine Drug Resistance Bacterial Tuberculosis Multidrug-Resistant Medicine Humans Young adult Child Mexico Tuberculosis Pulmonary media_common Aged Aged 80 and over biology Traditional medicine business.industry Sputum General Medicine Middle Aged biology.organism_classification medicine.disease Confidence interval First-line anti-TB drugs Infectious Diseases Female Trends medicine.symptom business |
| Zdroj: | International Journal of Infectious Diseases. 15(4):e272-e276 |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2011.01.001 |
| Popis: | Summary Background In 1997 the US Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO) reported high proportions of drug-resistant Mycobacterium tuberculosis in three Mexican states: Sinaloa, Baja California, and Oaxaca. In 2006, we showed that resistance to anti-tuberculosis drugs remained frequent in Sinaloa. Objectives The objectives of this study were to describe drug-resistant tuberculosis (TB) trends and to investigate the probability that patients acquire resistance to first-line anti-TB drugs on recurrence after treatment in Sinaloa. Methods Sputum specimens were collected from patients diagnosed with TB at all the health care institutions of Sinaloa during 1997–2005. Isolates were tested for susceptibility to first-line drugs. Results Among 671 isolates tested from 1997 to 2002, the overall resistance rate was 34.9% (95% confidence interval (CI) 31.2–38.4) with a 1.2% increase per year (Chi-square=4.258, p =0.03906). The prevalence of multi-drug resistance (MDR) was 17.9% (95% CI 14.9–20.7) with a 1.2% increase per year (Chi-square=8.352, p =0.00385). Of 50 patients registered twice between 1997 and 2005, 15 were fully susceptible at first registration, of whom six (40%) acquired drug resistance. Of 35 cases with any drug resistance at first registration, 21 (60%) came to acquire resistance to at least one other drug. Conclusions The proportion of drug-resistant TB increased during 1997–2005 in Sinaloa. Major efforts are needed to prevent the further rise and spread of drug-resistant and MDR TB. |
| Databáze: | OpenAIRE |
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