Hormonal regulation of acid cholesterol ester hydrolase activity: effects of triiodothyronine and 17α-ethynylestradiol
| Autor: | Hayden Lj, David L. Severson, Fletcher T |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
medicine.medical_specialty Physiology Stimulation Biology Ethinyl Estradiol Physiology (medical) Internal medicine Acetylglucosaminidase medicine Animals Pharmacology chemistry.chemical_classification Triiodothyronine Catabolism Thyroid Proteins Rats Inbred Strains General Medicine Hydrogen-Ion Concentration Sterol Esterase Rats Lipoproteins LDL medicine.anatomical_structure Endocrinology Enzyme Adipose Tissue Liver chemistry Hepatocyte lipids (amino acids peptides and proteins) Carboxylic Ester Hydrolases Hormone Lipoprotein |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 62:244-247 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/y84-037 |
| Popis: | Cholesterol ester hydrolase activity was measured in isolated rat hepatocytes and adipocytes. Administration of triiodothyronine to rats resulted in a specific and selective increase in lysosomal acid (pH 4.5) cholesterol ester hydrolase activity in hepatocytes. Since the majority of lipoprotein degradation occurs in liver parenchymal cells (hepatocytes), the stimulation of liver (hepatocyte) acid cholesterol ester hydrolase activity by triiodothyronine could contribute to the hypocholesterolemie action of thyroid hormones. Treatment of rats with 17α-ethynylestradiol to increase the hepatic degradation of lipoproteins did not change acid cholesterol ester hydrolase activity in liver, indicating that the thyroid hormone induced stimulation of acid cholesterol ester hydrolase activity in hepatocytes is not a secondary effect owing to the increased hepatic catabolism of low density lipoproteins (LDL). In contrast to the results with hepatocytes, hyperthyroidism did not increase acid cholesterol ester hydrolase activity in rat adipocytes. |
| Databáze: | OpenAIRE |
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