Transmission of Dapsone-Resistant Leprosy Detected by Molecular Epidemiological Approaches
| Autor: | Florenda M. Orcullo, Rama Murthy Sakamuri, Vidyagouri Shinde, Patrick J. Brennan, Varalakshmi D. Vissa, Indira Nath, Armi Maghanoy, Danielle E. Lyons, Marivic Balagon, Esterlina V. Tan, Irene B. Mallari, Wei Li, Edred Lao Dela Pena |
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| Rok vydání: | 2011 |
| Předmět: |
Philippines
India Leprostatic Agents Leprostatic agent Drug resistance Dapsone medicine.disease_cause Epidemiology and Surveillance Bacterial Proteins Leprosy medicine Humans Pharmacology (medical) Mycobacterium leprae Pharmacology Molecular Epidemiology Mutation biology Molecular epidemiology biology.organism_classification rpoB medicine.disease Virology Infectious Diseases Immunology Rifampin medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 55:5384-5387 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.05236-11 |
| Popis: | Drug resistance surveillance identified six untreated leprosy patients in the Philippines with Mycobacterium leprae folP1 mutations which confer dapsone resistance. Five patients share a village of residence; four who carried the mutation, Thr53Val, were also linked by M. leprae variable-number tandem repeat (VNTR) strain types. In India, folP1 mutations were detected in two relapse patients with a history of dapsone treatment. Mutations were not found in the rifampin target gene rpoB . These findings indicate that dapsone resistance is being transmitted. |
| Databáze: | OpenAIRE |
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