Preclinical Testing of Vaccines and Therapeutics for Gonorrhea in Female Mouse Models of Lower and Upper Reproductive Tract Infection
| Autor: | Andrew N. Macintyre, Gregory D. Sempowski, Kristie L. Connolly, Ann E. Jerse, Allison C Costenoble-Caherty, Michelle Pilligua-Lucas, Knashka Underwood, Anthony Soc, Carolina Gomez |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.drug_class
Gonorrhea Antibiotics urologic and male genital diseases medicine.disease_cause Reproductive Tract Infections Mice Immune system Anti-Infective Agents In vivo Pelvic Inflammatory Disease Supplement Pelvic inflammatory disease Animals Immunology and Allergy Medicine business.industry Vaginal microbicide medicine.disease Neisseria gonorrhoeae female genital diseases and pregnancy complications Disease Models Animal Infectious Diseases medicine.anatomical_structure Immunology Vagina Female business Pelvic Inflammatory Disease |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiab211 |
| Popis: | Murine models of Neisseria gonorrhoeae lower reproductive tract infection are valuable systems for studying N. gonorrhoeae adaptation to the female host and immune responses to infection. These models have also accelerated preclinical testing of candidate therapeutic and prophylactic products against gonorrhea. However, because N. gonorrhoeae infection is restricted to the murine cervicovaginal region, there is a need for an in vivo system for translational work on N. gonorrhoeae pelvic inflammatory disease (PID). Here we discuss the need for well-characterized preclinical upper reproductive tract infection models for developing candidate products against N. gonorrhoeae PID, and report a refinement of the gonorrhea mouse model that supports sustained upper reproductive tract infection. To establish this new model for vaccine testing, we also tested the licensed meningococcal 4CMenB vaccine, which cross-protects against murine N. gonorrhoeae lower reproductive tract infection, for efficacy against N. gonorrhoeae in the endometrium and oviducts following transcervical or vaginal challenge. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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