EphA3 Downregulation by Hypermethylation Associated with Lymph Node Metastasis and TNM Stage in Colorectal Cancer
| Autor: | Baocheng Wang, Yueming Sun, Yong Wang, Chuan Zhang, Zhuoqi Xuan, Jiandong Wang, Dongsheng Zhang |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Physiology Somatic cell Colorectal cancer Down-Regulation medicine.disease_cause Metastasis 03 medical and health sciences 0302 clinical medicine medicine Humans Promoter Regions Genetic Neoplasm Staging business.industry Receptor EphA3 Gastroenterology Receptor Protein-Tyrosine Kinases Methylation DNA Methylation Middle Aged medicine.disease HCT116 Cells digestive system diseases Gene Expression Regulation Neoplastic CpG site 030220 oncology & carcinogenesis Lymphatic Metastasis DNA methylation Cancer research Immunohistochemistry 030211 gastroenterology & hepatology CpG Islands Female Carcinogenesis business Colorectal Neoplasms HT29 Cells |
| Zdroj: | Digestive diseases and sciences. 64(6) |
| ISSN: | 1573-2568 |
| Popis: | EphA3 is a member of Eph receptors, which is involved in tumorigenesis. The expression and clinical significance of EphA3 in colorectal cancer (CRC) have not been fully investigated. Four colon cancer cell lines and a set of CRC tissues were examined for EphA3 expression. The methylation status of a CpG island within the EphA3 promoter, the presence of four somatic EPHA3 mutations, and EPHA3 gene copy number variations were also analyzed in colon cancer cell lines. EphA3 expression was lost in all colon cancer cell lines examined. EphA3 expression was lower in tumor tissues when compared with normal intestinal tissues (P |
| Databáze: | OpenAIRE |
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