Synthesis and characterization of critical process related impurities of an asthma drug – Zafirlukast
| Autor: | Vurimidi Himabindu, Anumula Raghupathi Reddy, Gilla Goverdhan, Ghanta Mahesh Reddy |
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| Rok vydání: | 2014 |
| Předmět: |
Drug
Leukotriene Chemistry(all) Leukotriene receptor Chemistry media_common.quotation_subject Antagonist Process impurities General Chemistry Pharmacology medicine.disease lcsh:Chemistry lcsh:QD1-999 medicine Zafirlukast Asthma drug Related impurities Asthma media_common medicine.drug Pulmonary disorders |
| Zdroj: | Journal of Saudi Chemical Society, Vol 18, Iss 2, Pp 129-138 (2014) |
| ISSN: | 1319-6103 |
| Popis: | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the treatment of pulmonary disorders such as asthma. During the process development of zafirlukast, eight process related impurities were observed at a level of 0.1–0.15 area percent. Synthesis and characterization of these impurities and investigation of the root cause of their formation is described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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