MK2 Signaling: Lessons on Tissue Specificity in Modulation of Inflammation
| Autor: | Sampsa Matikainen, Antti Lauerma, Nanna Fyhrquist |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cell signaling
Inflammation Dermatology Protein Serine-Threonine Kinases Models Biological p38 Mitogen-Activated Protein Kinases Biochemistry Mice Skin Physiological Phenomena medicine Animals Humans Molecular Biology Skin business.industry Inflammatory skin disease Intracellular Signaling Peptides and Proteins Cell Biology Tissue specificity Gene Expression Regulation Immunology medicine.symptom business Target organ Signal Transduction |
| Zdroj: | Journal of Investigative Dermatology. 130:342-344 |
| ISSN: | 0022-202X |
| Popis: | MK2 is a promising candidate for treating inflammation. Mice deficient in MK2 were studied in models of inflammation to see whether MK2 could be a useful target in inflammatory skin disease. Surprisingly, MK2 played only a minor role in skin inflammation, indicating that modulation of cell signaling gives different results depending on the models of inflammation and target organs that are studied. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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