Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease
Autor: | Marjolein Garsen, Ganqi Wang, Michael Elkin, Johan van der Vlag, Ton J. Rabelink, Bernard M. van den Berg |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Cell signaling Cell Survival Cell Biology Extracellular matrix 03 medical and health sciences chemistry.chemical_compound medicine Animals Humans Heparanase Glucuronidase Autophagy Heparan sulfate medicine.disease Extracellular Matrix Cell biology 030104 developmental biology medicine.anatomical_structure Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] chemistry Nephrology Immunology Glomerular Filtration Barrier Kidney Diseases Kidney disease |
Zdroj: | Nature Reviews. Nephrology, 13, 4, pp. 201-212 Nature Reviews Nephrology, 13(4), 201-212 Nature Reviews. Nephrology, 13, 201-212 |
ISSN: | 1759-5061 |
Popis: | Item does not contain fulltext Heparanase has regulatory roles in various processes, including cell communication, gene transcription and autophagy. In addition, it is the only known mammalian endoglycosidase that is capable of degrading heparan sulfate (HS). HS chains are important constituents and organizers of the extracellular matrix (ECM), and have a key role in maintaining the integrity and function of the glomerular filtration barrier. In addition, HS chains regulate the activity of numerous bioactive molecules, such as cytokines and growth factors, at the cell surface and in the ECM. Given the functional diversity of HS, its degradation by heparanase profoundly affects important pathophysiological processes, including tumour development, neovascularization and inflammation, as well as progression of kidney disease. Heparanase-mediated degradation and subsequent remodelling of HS in the ECM of the glomerulus is a key mechanism in the development of glomerular disease, as exemplified by the complete resistance of heparanase-deficient animals to diabetes and immune-mediated kidney disease. This Review summarizes the role of heparanase in the development of kidney disease, and its potential as a therapeutic target. |
Databáze: | OpenAIRE |
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