Correlation between plasma calcium, parathyroid hormone (PTH) and the metabolic syndrome (MetS) in a community-based cohort of men and women
| Autor: | Tommy Ahlström, Emil Hagström, Per Hellman, Claes Rudberg, Lars Lind, Anders Larsson |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Parathyroid hormone Context (language use) macromolecular substances Cohort Studies Endocrinology Insulin resistance Internal medicine medicine Confidence Intervals Humans Aged Metabolic Syndrome business.industry medicine.disease Parathyroid Hormone Cohort Linear Models Calcium Female Metabolic syndrome business Body mass index Primary hyperparathyroidism Cohort study |
| Zdroj: | Clinical endocrinology. 71(5) |
| ISSN: | 1365-2265 |
| Popis: | In recent years, an association has been noted between several abnormalities that characterize the metabolic syndrome (MetS) and primary hyperparathyroidism (pHPT). These abnormalities include dyslipidaemia, obesity, insulin resistance and hypertension. The correlations between plasma calcium, parathyroid hormone (PTH) and the variables in the MetS in a normal population are still unclear.To describe correlations between plasma calcium and PTH and the various abnormalities present in the MetS in a healthy population.We studied 1016 healthy individuals from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) population of 70 years old, by means of plasma analyses of calcium, PTH, creatinine, lipids, insulin and glucose, as well as by standardized blood pressure measurements. Further, body mass index (BMI) and waist circumference were determined.The more National Cholesterol Education Program (NCEP) criteria for the MetS that were met, the higher the s-PTH and albumin-corrected s-calcium. Further, positive correlations between plasma calcium and BMI (P = 0.0003), waist circumference (P = 0.0009) and insulin resistance (P = 0.079) were found. PTH and BMI (P0.0001), waist circumference (P0.0001), systolic blood pressure (P = 0.0034), diastolic blood pressure (P = 0.0008), serum triglycerides (P = 0.0003) and insulin resistance (P = 0.0003) were positively correlated, whereas serum high density lipoproteins (HDL) (P = 0.036) and PTH were negatively correlated.We conclude that PTH correlates with several of the metabolic factors included in the MetS within a normocalcaemic population. In addition, individuals with mild pHPT present significantly more NCEP criteria for MetS. We postulate that increased levels of PTH in pHPT may be associated with the increased cardiovascular morbidity and mortality seen in pHPT. |
| Databáze: | OpenAIRE |
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