The Sledgehammer in Precision Medicine: Dexamethasone and Immunotherapeutic Treatment of Glioma
| Autor: | Pavan S. Upadhyayula, Eleonora F Spinazzi, Cheng-Chia Wu, Michael G Argenziano, Peter Canoll, Jeffrey N. Bruce, Dominique M. Higgins |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research T cell Lymphocyte medicine.medical_treatment Dexamethasone 03 medical and health sciences Mice 0302 clinical medicine Immune system Lymphocytes Tumor-Infiltrating Glioma Tumor Microenvironment Medicine Animals Humans Precision Medicine B cell business.industry Brain Neoplasms Monocyte General Medicine Immunotherapy medicine.disease 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research business Glioblastoma medicine.drug |
| Zdroj: | Cancer investigation. 40(6) |
| ISSN: | 1532-4192 |
| Popis: | Understanding dexamethasone's effect on the immune microenvironment in glioma patients is of key importance. We performed a comprehensive literature review using the NCBI PubMed database for all articles meeting the following search criteria. ((dexamethasone[All Fields]) AND (glioma or glioblastoma)[Title/Abstract]) AND (immune or T cell or B cell or monocyte or neutrophil or macrophage). Forty-three manuscripts were deemed relevant to the topic at hand. Multiple clinical studies have linked dexamethasone use to decreased overall survival while preclinical studies in murine glioma models have demonstrated decreased tumor-infiltrating lymphocytes after dexamethasone administration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|