Wireless Addressable Cortical Microstimulators Powered by Near-Infrared Harvesting
| Autor: | Arto V. Nurmikko, Jungwoo Jang, Ah-Hyoung Lee, Jihun Lee, Yoon-Kyu Song |
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| Rok vydání: | 2021 |
| Předmět: |
Fluid Flow and Transfer Processes
Light business.industry Computer science Process Chemistry and Technology Photovoltaic system Electrical engineering Bioengineering Synthetic biological circuit Prostheses and Implants Rats Identification (information) Application-specific integrated circuit Proof of concept Telecommunications link Microstimulation Wireless Animals business Instrumentation |
| Zdroj: | ACS sensors. 6(7) |
| ISSN: | 2379-3694 |
| Popis: | Ensembles of autonomous, spatially distributed wireless stimulators can offer a versatile approach to patterned microstimulation of biological circuits such as the cortex. Here, we demonstrate the concept of a distributed, untethered, and addressable microstimulator, integrating an ultraminiaturized ASIC with a custom-designed GaAs photovoltaic (PV) microscale energy harvester, dubbed as an "optical neurograin (ONG)". An on-board Manchester-encoded near-infrared downlink delivers incident IR power and provides a synchronous clock across an ensemble of microdevices, triggering stimulus events by remote command. Each ONG has a unique device address and, when an incoming downlink bit sequence matches with this device identification (ID), the implant delivers a charge-balanced current stimulus to the target cortex. Present devices use 7-bit metal fuses fabricated during the CMOS process for their device ID, laser-scribed in post-processing, allowing in principle for a stimulator network of up to 128 nodes. We have characterized small ensembles of ONGs and shown a proof of concept of the system both on benchtop and in vivo rat rodent model. |
| Databáze: | OpenAIRE |
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