Green coffee extract enhances oxidative stress resistance and delays aging in Caenorhabditis elegans
| Autor: | Carlotta Ciaramelli, Cristina Airoldi, Ivano De Noni, Milda Stuknytė, Loredana Amigoni, Maria Elena Regonesi, Alessandro Palmioli, Ilaria Bruni, Chiara Magoni |
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| Přispěvatelé: | Amigoni, L, Stuknytė, M, Ciaramelli, C, Magoni, C, Bruni, I, De Noni, I, Airoldi, C, Regonesi, M, Palmioli, A |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment media_common.quotation_subject Medicine (miscellaneous) Green coffee extract medicine.disease_cause 01 natural sciences High resolution mass spectrometry 03 medical and health sciences NMR spectroscopy Antioxidant activity CHIM/06 - CHIMICA ORGANICA medicine TX341-641 Healthy aging Caenorhabditis elegans Caenorhabditis elegan media_common Nutrition and Dietetics biology Chemistry Nutrition. Foods and food supply 010401 analytical chemistry Longevity Chlorogenic acid Stress resistance biology.organism_classification BIO/10 - BIOCHIMICA 0104 chemical sciences 030104 developmental biology Biochemistry Polyphenol Chlorogenic acids Oxidative stress Food Science |
| Zdroj: | Journal of Functional Foods, Vol 33, Iss, Pp 297-306 (2017) |
| ISSN: | 1756-4646 |
| Popis: | Nutritional factors play a pivotal role for healthy aging and longevity. This is related to the antioxidant properties of the molecules present in some foods. Due to the high content of polyphenols, Green Coffee Extract (GCE) is a powerful antioxidant. Nevertheless, little is known about its effect on aging. We demonstrated the benefic effects of GCE on stress resistance, fertility and adult mean lifespan using Caenorhabditis elegans as a model. The mean and maximum lifespan of worms treated with GCE increased significantly in a dose-dependent manner, and animals pre-treated were more resistant to oxidative stress. NMR and UPLC/ESI-HRMS analyses of GCE confirmed a significant content of chlorogenic acids, being 5-O-caffeoylquinic acid (5-CQA) the most abundant isomer. The major activity demonstrated by GCE in comparison to the pure 5-CQA on C. elegans phenotypes clearly demonstrated the importance of the employment of a natural extract to develop functional foods and supplements. |
| Databáze: | OpenAIRE |
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