Circular RNAs serve as miRNA sponges in breast cancer
| Autor: | Yuksel Aliyazicioglu, Ceylan Hepokur, Francisco J. Enguita, Sema Misir |
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| Přispěvatelé: | Repositório da Universidade de Lisboa |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Carcinogenesis miRNA sponge Antineoplastic Agents Breast Neoplasms Disease Malignancy Noncoding RNA 03 medical and health sciences 0302 clinical medicine Breast cancer Surgical oncology microRNA medicine Humans Pharmacology (medical) Radiology Nuclear Medicine and imaging skin and connective tissue diseases business.industry Antagomirs RNA Circular General Medicine medicine.disease Non-coding RNA Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Female circRNAs business Large group Biogenesis |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | © The Japanese Breast Cancer Society 2020 Circular RNAs are a large group of non-coding RNAs with a closed-loop structure. circRNAs play significant roles in many biological processes as miRNA sponges, regulators for gene transcription, combining with RNA-binding proteins and translation of protein. Nowadays, circRNAs have become a research hotspot in the field of cancer and molecular biology. Accumulating evidences have indicated that circRNAs participate in the initiation and development of various cancers such as breast cancer. Breast cancer is a heterogeneous disease, which is the most common malignancy in women. The incidence and mortality rates of breast cancer indicate that it is the leading cause of cancer-related deaths. The goal of the present review is to introduce biogenesis, function characteristics and types of circRNAs, and also their biological functions on breast cancer, especially as miRNA sponges. Additionally, we discuss their use as a new therapeutic target for the treatment of breast cancer. |
| Databáze: | OpenAIRE |
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