Both maternal care received and genotype influence stress-related phenotype in female rats
| Autor: | Oscar E. Vasquez, Aya Dudin, Alison S. Fleming, Patrick O. McGowan, Daeria O. Lawson, Pauline Pan, Marla B. Sokolowski |
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| Rok vydání: | 2018 |
| Předmět: |
Litter (animal)
Genotype Offspring Physiology Single-nucleotide polymorphism Anxiety Polymorphism Single Nucleotide Tacrolimus Binding Proteins 03 medical and health sciences Behavioral Neuroscience Receptors Glucocorticoid 0302 clinical medicine Developmental Neuroscience Genetic variation Developmental and Educational Psychology Animals Rats Long-Evans 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Allele Maternal Behavior Serotonin transporter Serotonin Plasma Membrane Transport Proteins Behavior Animal biology 05 social sciences Phenotype Rats 3. Good health biology.protein Female Stress Psychological 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Developmental Psychobiology. 60:889-902 |
| ISSN: | 0012-1630 |
| DOI: | 10.1002/dev.21770 |
| Popis: | Rat dams differ naturally in the level of maternal care they provide to their offspring within the same litter. We explored possible mechanisms of differential maternal care focused on genetic variation. We examined single nucleotide polymorphisms in the glucocorticoid receptor, FK506-binding protein, and serotonin transporter genes in two separate cohorts, and the relationship between differential maternal care received, genotype, and offspring phenotype. Allelic variation in all three genes was significantly associated with levels of maternal care received by offspring and behavioral and endocrine stress responses in adulthood. Differences in pup behavior were also associated with allelic variation in these genes. Together, these results indicate that the dam/pup interaction is dynamic and implicate the genotype of the offspring in influencing the level of maternal care received. They further suggest that some genotypes may have a dampening effect on the impact of maternal care on stress-related phenotypes in adulthood. |
| Databáze: | OpenAIRE |
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