The Effects of Pancreatic Microcirculatory Disturbances on Histopathologic Tissue Damage and the Outcome in Severe Acute Pancreatitis
| Autor: | Oliver Mann, Maximilian Bockhorn, Kai Bachmann, Andrea Hinsch, Jakob R. Izbicki, Anna Duprée, Lena Tomkötter, Constantin Trepte, Johannes Erbes |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Swine Endocrinology Diabetes and Metabolism macromolecular substances Severity of Illness Index Microcirculation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Severity of illness Internal Medicine medicine Animals Pancreas Survival analysis Pancreatic duct Hepatology business.industry medicine.disease Survival Analysis Oxygen medicine.anatomical_structure Glycodeoxycholic acid chemistry Pancreatitis 030220 oncology & carcinogenesis Glycodeoxycholic Acid Acute Disease Acute pancreatitis 030211 gastroenterology & hepatology business |
| Zdroj: | Pancreas. 45(2) |
| ISSN: | 1536-4828 |
| Popis: | OBJECTIVES Severe acute pancreatitis is an inflammatory disease of the pancreas with a high morbidity and mortality. To date, no causal treatment is known. The aim of the present study was to analyze the impact of pancreatic microcirculatory disturbances in severe acute pancreatitis and to correlate the effects with histopathologic tissue damage and outcome. METHODS Severe acute pancreatitis was induced in 129 pigs by injection of glycodeoxycholic acid into the pancreatic duct. Pancreatic microcirculation, pancreatic tissue oxygenation, histopathologic tissue damage, and survival were measured and analyzed. RESULTS Our study demonstrates a strong correlation between pancreatic microcirculatory disturbances and histopathologic tissue damage (r = 0.728; P < 0.001). Furthermore, we showed a strong correlation between tissue oxygenation and the severity of the pancreatitis according to an established porcine pancreatitis score (r = 0.694; P < 0.001). In addition, disturbances of the pancreatic microcirculation were shown to be associated with an increased mortality rate in severe acute pancreatitis. CONCLUSIONS We found that pancreatic microcirculatory disturbances have significant effects on histopathologic tissue damage and the outcome of severe acute pancreatitis. For a better survival of severe acute pancreatitis, the treatment should focus on an improvement of pancreatic microcirculation. |
| Databáze: | OpenAIRE |
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