| Autor: |
Shinichi Hikasa, Shota Shimabukuro, Kyoko Hideta, Satoshi Higasa, Akihiro Sawada, Tazuko Tokugawa, Kuniyoshi Tanaka, Mina Yanai, Takeshi Kimura |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
HIV medicineREFERENCES. |
| ISSN: |
1468-1293 |
| Popis: |
To compare the impact of tenofovir alafenamide (TAF) on the slope of the estimated glomerular filtration rate (eGFR) with that of abacavir in Japanese patients living with HIV infection.The participants in this single-centre, retrospective, observational study were Japanese patients with HIV infection who started antiretroviral therapy with TAF/emtricitabine or abacavir/lamivudine or were switched from tenofovir disoproxil fumarate/emtricitabine to TAF/emtricitabine or abacavir/lamivudine (anchor drugs remained constant) between January 2012 and December 2020. The eGFR slope was defined as the regression coefficient between eGFR and time. The study outcome was rapid kidney function decline (RKFD; eGFR slope -5 mL/min/1.73 mThe study included 184 patients (with 2835 eGFR data points). The median duration of exposure to TAF or abacavir was 2.6 years [interquartile range (IQR): 1.7-3.3], and the median eGFR slope was -4.1 mL/min/1.73 mThese findings suggest that renal function should be monitored carefully after the initiation of TAF in Japanese patients with HIV infection. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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