A Commonly Recognized Simian Immunodeficiency Virus Nef Epitope Presented to Cytotoxic T Lymphocytes of Indian-Origin Rhesus Monkeys by the Prevalent Major Histocompatibility Complex Class I Allele Mamu-A*02
| Autor: | Marcelo J. Kuroda, Suzanne Robinson, Carol I. Lord, Michael H. Newberg, William A. Charini, Norman L. Letvin |
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| Rok vydání: | 2001 |
| Předmět: |
animal diseases
viruses Molecular Sequence Data Immunology Genes MHC Class I medicine.disease_cause Major histocompatibility complex Microbiology Gene Products nef Epitope Epitopes Immune system Virology Vaccines and Antiviral Agents MHC class I medicine Animals Cytotoxic T cell Amino Acid Sequence Alleles biology Histocompatibility Antigens Class I virus diseases Simian immunodeficiency virus Macaca mulatta CTL Insect Science biology.protein Simian Immunodeficiency Virus CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | Journal of Virology. 75:10179-10186 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.75.21.10179-10186.2001 |
| Popis: | The ability to monitor vaccine-elicited CD8+cytotoxic T-lymphocyte (CTL) responses in simian immunodeficiency virus (SIV)- and simian-human immunodeficiency virus (SHIV)-infected rhesus monkeys has been limited by our knowledge of viral epitopes predictably presented to those lymphocytes by common rhesus monkey MHC class I alleles. We now define an SIV and SHIV Nef CTL epitope (YTSGPGIRY) that is presented to CD8+T lymphocytes by the common rhesus monkey MHC class I molecule Mamu-A*02. All seven infectedMamu-A*02+monkeys evaluated demonstrated this response, and peptide-stimulated interferon gamma Elispot assays indicated that the response represents a large proportion of the entire CD8+T-lymphocyte SIV- or SHIV-specific immune response of these animals. Knowledge of this epitope and MHC class I allele substantially increases the number of available rhesus monkeys that can be used for testing prototype HIV vaccines in this important animal model. |
| Databáze: | OpenAIRE |
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