Optical coherence tomography angiography and Humphrey visual field in patients with obstructive sleep apnea

Autor:	Arash, Davanian, Lindsay, Williamson, Caitlen, Taylor, Abigail, Harrover, Kathryn, Bollinger, Bashir, Chaudhary, Varsha, Taskar, Tae Jin, Lee, Yuhan, Liu, Qingxia, Chen, Dennis M, Marcus
Rok vydání:	2022
Předmět:	Retinal Ganglion Cells Pulmonary and Respiratory Medicine Sleep Apnea Obstructive Cross-Sectional Studies Neurology Angiography Humans Glaucoma Prospective Studies Neurology (clinical) Visual Fields Tomography Optical Coherence
Zdroj:	Journal of Clinical Sleep Medicine. 18:2133-2142
ISSN:	1550-9397 1550-9389
Popis:	To determine if obstructive sleep apnea syndrome (OSAS) predisposes patients to glaucoma and macular disease due to vascular compromise by evaluating retinal and optic nerve vasculature and function using optical coherence tomography angiography and Humphrey visual field testing, respectively.In this prospective, observational, cross-sectional study 45 patients undergoing polysomnography ordered per standard of care were selected and stratified based on apnea-hypopnea index (AHI). Medical history, visual acuity testing, 24-2 Humphrey visual field, intraocular pressure measurement, and optical coherence tomography angiography studies of the macular and peripapillary retina were obtained. Correlations between polysomnography parameters and imaging data were analyzed.The radial peripapillary capillary vascular density demonstrated no relationship to AHI (95% confidence interval [CI] [-0.026,0.038]) or severity of OSAS (95% CI: [-0.772, 3.648]) for moderate OSAS compared to mild/normal and (-1.295, 3.1421) for severe compared to mild/normal. Optical coherence tomography angiography superficial parafoveal vascular density (95% CI: [-0.068,0.011], deep parafoveal vascular density (95% CI: [-0.080,0.009]), and foveal avascular zone (95% CI: [-0.001, 0.001]) showed no statistically significant relationship to AHI or OSAS severity after controlling for confounders. Optical coherence tomography retinal nerve fiber layer thickness increased with AHI (The severity of OSAS did not show a statistically significant effect on parameters associated with glaucoma or macular vascular disease. Larger cohorts may be required to determine the physiologic consequences of OSAS on the macular and optic nerve vasculature, structure, and function.Davanian A, Williamson L, Taylor C, et al. Optical coherence tomography angiography and Humphrey visual field in patients with obstructive sleep apnea.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8012201c5609ecaebaa416ec8764ed96 https://doi.org/10.5664/jcsm.10054 Zobrazit plný text záznamu