Macrophage‐fibroblast circuits in the spleen

Autor: Rachel Golub, Alicia Bellomo, Marc Bajénoff, Rebecca Gentek
Přispěvatelé: Trafic Vésiculaire, Réponse Innée et Virus – Vesicular trafficking, Innate response, Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Edinburgh, Lymphopoïèse (Lymphopoïèse (UMR_1223 / U1223 / U-Pasteur_4)), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), This review was funded by grants from the Agence National pour la Recherche (ANR-17-CE15-0015-01), the Fondation pour la Recherche Médicale (FRM : FDT201904007871), the University of Edinburgh, the Kennedy Trust for Rheumatology Research (KENN 19 20 07) and from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program grant agreement 647257- STROMA. This work was supported by institutional grants from INSERM, CNRS, and Aix-Marseille University to the CIML., ANR-17-CE15-0015,StroMAC,Cross-talk des macrophages et du stroma au sein du ganglion lymphatique(2017), European Project: 647257,H2020,ERC-2014-CoG,STROMA(2015), Vougny, Marie-Christine, Cross-talk des macrophages et du stroma au sein du ganglion lymphatique - - StroMAC2017 - ANR-17-CE15-0015 - AAPG2017 - VALID, IMMUNOBIOLOGY OF LYMPHOID STROMAL CELLS - STROMA - - H20202015-10-01 - 2020-09-30 - 647257 - VALID, Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Immunological Reviews
Immunological Reviews, 2021, 302 (1), pp.104-125. ⟨10.1111/imr.12979⟩
Immunological Reviews, Wiley, 2021, 302 (1), pp.104-125. ⟨10.1111/imr.12979⟩
ISSN: 0105-2896
1600-065X
DOI: 10.1111/imr.12979⟩
Popis: International audience; Macrophages are an integral part of all organs in the body, where they contribute to immune surveillance, protection, and tissue-specific homeostatic functions. This is facilitated by so-called niches composed of macrophages and their surrounding stroma. These niches structurally anchor macrophages and provide them with survival factors and tissue-specific signals that imprint their functional identity. In turn, macrophages ensure appropriate functioning of the niches they reside in. Macrophages thus form reciprocal, mutually beneficial circuits with their cellular niches. In this review, we explore how this concept applies to the spleen, a large secondary lymphoid organ whose primary functions are to filter the blood and regulate immunity. We first outline the splenic micro-anatomy, the different populations of splenic fibroblasts and macrophages and their respective contribution to protection of and key physiological processes occurring in the spleen. We then discuss firmly established and potential cellular circuits formed by splenic macrophages and fibroblasts, with an emphasis on the molecular cues underlying their crosstalk and their relevance to splenic functionality. Lastly, we conclude by considering how these macrophage-fibroblast circuits might be impaired by aging, and how understanding these changes might help identify novel therapeutic avenues with the potential of restoring splenic functions in the elderly.
Databáze: OpenAIRE
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