Inhibitors of 17β-hydroxysteroid dehydrogenase type 1, 2 and 14: Structures, biological activities and future challenges
| Autor: | Mohamed Salah, Martin Frotscher, Ahmed S. Abdelsamie |
|---|---|
| Přispěvatelé: | HIPS, Helmholtz-Institut füt Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany. |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
17-Hydroxysteroid Dehydrogenases medicine.drug_class Steroidogenic enzymes 030209 endocrinology & metabolism Dehydrogenase Biochemistry Hydroxysteroid dehydrogenases 03 medical and health sciences 0302 clinical medicine Endocrinology Biological property Steroid sulfatase medicine Estrogen dependent diseases Humans Hydroxysteroid dehydrogenase Enzyme Inhibitors Molecular Biology chemistry.chemical_classification Enzyme inhibitors Hydroxysteroid Dehydrogenases 030104 developmental biology Enzyme chemistry Estrogen Steroids Signal transduction hormones hormone substitutes and hormone antagonists |
| Zdroj: | Molecular and cellular endocrinology |
| ISSN: | 1872-8057 |
| Popis: | During the past 25 years, the modulation of estrogen action by inhibition of 17β-hydroxysteroid dehydrogenase types 1 and 2 (17β-HSD1 and 17β-HSD2), respectively, has been pursued intensively. In the search for novel treatment options for estrogen-dependent diseases (EDD) and in order to explore estrogenic signaling pathways, a large number of steroidal and nonsteroidal inhibitors of these enzymes has been described in the literature. The present review gives a survey on the development of inhibitor classes as well as the structural formulas and biological properties of their most interesting representatives. In addition, rationally designed dual inhibitors of both 17β-HSD1 and steroid sulfatase (STS) as well as the first inhibitors of 17β-HSD14 are covered. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect