Molecular Evolution of Peptide Methionine Sulfoxide Reductases (MsrA and MsrB): On the Early Development of a Mechanism That Protects Against Oxidative Damage
| Autor: | Leslie E. Orgel, Antonio Lazcano, Luis Delaye, Arturo Becerra |
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| Rok vydání: | 2006 |
| Předmět: |
Peptide
Evolution Molecular chemistry.chemical_compound Bacterial Proteins Molecular evolution RNA Ribosomal 16S RNA Ribosomal 18S Genetics Animals Humans Methionine synthase Symbiosis Molecular Biology Phylogeny Ecology Evolution Behavior and Systematics chemistry.chemical_classification Methionine biology Microfilament Proteins Oxidative Stress Enzyme chemistry Biochemistry Methionine Sulfoxide Reductases Horizontal gene transfer biology.protein Methionine sulfoxide reductase Oxidoreductases Transcription Factors MSRA |
| Zdroj: | Journal of Molecular Evolution. 64:15-32 |
| ISSN: | 1432-1432 0022-2844 |
| DOI: | 10.1007/s00239-005-0281-2 |
| Popis: | Methionine sulfoxide reductases, enzymes that reverse the oxidation of methionine residues, have been described in a wide range of species. The reduction of the diastereoisomers of oxidized methionine is catalyzed by two different monomeric methionine sulfoxide reductases (MsrA and MsrB) and is best understood as an evolutionary response to high levels of oxygen either in the Earth's atmosphere or possibly in more localized environments. Phylogenetic analyses of these proteins suggest that their distribution is the outcome of a complex history including many paralogy and lateral gene transfer events. |
| Databáze: | OpenAIRE |
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