Diabetes Due to Secretion of an Abnormal Insulin
| Autor: | Masashi Kobayashi, Howard S. Tager, B D Given, Mary E. Mako, Arthur H. Rubenstein, Russel Poucher, Orville G. Kolterman, James J Markese, David S. Baldwin, Jerrold M. Olefsky |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Chemical Phenomena medicine.medical_treatment Glucagon Insulin resistance Internal medicine Diabetes mellitus Diabetes Mellitus medicine Hyperinsulinemia Humans Insulin Proinsulin biology business.industry General Medicine Middle Aged Electrophoresis Disc medicine.disease Receptor Insulin Chemistry Insulin receptor Endocrinology medicine.anatomical_structure biology.protein Insulin Resistance Pancreas business |
| Zdroj: | New England Journal of Medicine. 302:129-135 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm198001173020301 |
| Popis: | A 51-year-old, nonobese man with diabetes mellitus had marked hyperinsulinemia (70 to 120 muU per milliliter; 502 to 860 pmol per liter) and fasting hyperglycemia (140 to 170 mg per 100 ml; 7.8 to 9.4 mmol per liter). Plasma proinsulin, glucagon, growth hormone, and cortisol levels were normal; insulin antibodies and insulin-receptor antibodies were not detected. The patient showed relatively normal insulin sensitivity, and insulin receptors on circulating monocytes were within the normal range. Insulin from the patient's serum bound to IM-9 lymphocytes and rat adipocytes approximately 40 per cent as well as insulin standards. Its biologic activity on rat adipocytes averaged 15 per cent of that expected from its immunologic concentration. The impaired biologic activity of this patient's circulating insulin was probably due to a structural abnormality. Subsequent studies of the patient's insulin (fortuitously obtained from his pancreas during a laparotomy for a pancreatic cyst) have confirmed this conclusion. (N Engl J Med 302:129-135, 1980). |
| Databáze: | OpenAIRE |
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